Thymosin β-10 gene expression as a possible tool in diagnosis of thyroid neoplasias

Gennaro Chiappetta, Francesca Pentimalli, Mario Monaco, Monica Fedele, Rosa Pasquinelli, Giovanna Maria Pierantoni, Maria Teresa Ribecco, Giovanni Santelli, Daniela Califano, Luciano Pezzullo, Alfredo Fusco

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Overexpression of thymosin β-10 (TB10) has been shown in rat thyroid transformed cell lines, and in human thyroid carcinoma tissues and cell lines. To investigate whether TB10 detection could be a valid tool in the diagnosis of human thyroid neoplasias, we extended the analysis of TB10 expression to a large number of thyroid hyperproliferative and neoplastic tissues using an immunohistochemical assay. Our analyses showed a TB10 positive staining in all human thyroid carcinomas particularly in the anaplastic histotypes, whereas no TB10 immunostaining was observed in normal thyroid, in adenomas and the majority of the goiters. These results suggest that the evaluation of TB10 gene expression may be considered a promising means of diagnosis of human thyroid hyperproliferative disorders.

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalOncology Reports
Volume12
Issue number2
Publication statusPublished - Aug 2004

Fingerprint

Thymosin
Thyroid Gland
Thyroid Neoplasms
Gene Expression
Neoplasms
Transformed Cell Line
Goiter
Staining and Labeling
Cell Line

Keywords

  • Immunohistochemistry
  • Neoplasia
  • Thymosin
  • Thyroid

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Chiappetta, G., Pentimalli, F., Monaco, M., Fedele, M., Pasquinelli, R., Pierantoni, G. M., ... Fusco, A. (2004). Thymosin β-10 gene expression as a possible tool in diagnosis of thyroid neoplasias. Oncology Reports, 12(2), 239-243.

Thymosin β-10 gene expression as a possible tool in diagnosis of thyroid neoplasias. / Chiappetta, Gennaro; Pentimalli, Francesca; Monaco, Mario; Fedele, Monica; Pasquinelli, Rosa; Pierantoni, Giovanna Maria; Ribecco, Maria Teresa; Santelli, Giovanni; Califano, Daniela; Pezzullo, Luciano; Fusco, Alfredo.

In: Oncology Reports, Vol. 12, No. 2, 08.2004, p. 239-243.

Research output: Contribution to journalArticle

Chiappetta, G, Pentimalli, F, Monaco, M, Fedele, M, Pasquinelli, R, Pierantoni, GM, Ribecco, MT, Santelli, G, Califano, D, Pezzullo, L & Fusco, A 2004, 'Thymosin β-10 gene expression as a possible tool in diagnosis of thyroid neoplasias', Oncology Reports, vol. 12, no. 2, pp. 239-243.
Chiappetta G, Pentimalli F, Monaco M, Fedele M, Pasquinelli R, Pierantoni GM et al. Thymosin β-10 gene expression as a possible tool in diagnosis of thyroid neoplasias. Oncology Reports. 2004 Aug;12(2):239-243.
Chiappetta, Gennaro ; Pentimalli, Francesca ; Monaco, Mario ; Fedele, Monica ; Pasquinelli, Rosa ; Pierantoni, Giovanna Maria ; Ribecco, Maria Teresa ; Santelli, Giovanni ; Califano, Daniela ; Pezzullo, Luciano ; Fusco, Alfredo. / Thymosin β-10 gene expression as a possible tool in diagnosis of thyroid neoplasias. In: Oncology Reports. 2004 ; Vol. 12, No. 2. pp. 239-243.
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