Thymosin Alpha 1 Mitigates Cytokine Storm in Blood Cells from Coronavirus Disease 2019 Patients

Claudia Matteucci, Antonella Minutolo, Emanuela Balestrieri, Vita Petrone, Marialaura Fanelli, Vincenzo Malagnino, Marco Ianetta, Alessandro Giovinazzo, Filippo Barreca, Silvia Di Cesare, Patrizia De Marco, Martino Tony Miele, Nicola Toschi, Antonio Mastino, Paola Sinibaldi Vallebona, Sergio Bernardini, Paola Rogliani, Loredana Sarmati, Massimo Andreoni, Sandro GrelliEnrico Garaci

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Coronavirus disease 2019 (COVID-19) is characterized by immune-mediated lung injury and complex alterations of the immune system, such as lymphopenia and cytokine storm, that have been associated with adverse outcomes underlining a fundamental role of host response in severe acute respiratory syndrome coronavirus 2 infection and the pathogenesis of the disease. Thymosin alpha 1 (Tα1) is one of the molecules used in the management of COVID-19, because it is known to restore the homeostasis of the immune system during infections and cancer. Methods: In this study, we captured the interconnected biological processes regulated by Tα1 in CD8+ T cells under inflammatory conditions. Results: Genes associated with cytokine signaling and production were upregulated in blood cells from patients with COVID-19, and the ex vivo treatment with Tα1-mitigated cytokine expression, and inhibited lymphocyte activation in a CD8+ T-cell subset specifically. Conclusion: These data suggest the potential role of Tα1 in modulating the immune response homeostasis and the cytokine storm in vivo.

Original languageEnglish
Article numberofaa588
JournalOpen Forum Infectious Diseases
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 1 2021

Keywords

  • cytokine storm
  • enrichment analysis
  • immune modulation
  • SARS-CoV-2
  • Thymosin alpha 1

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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