Abstract
The effects of different in vivo thymosin alpha one (Tα1) treatments on T-cell responses inhibited by cocaine abuse were studied. Administration during cocaine treatment promoted a faster recovery of normal natural killer (NK) cell activity after the suspension of abuse. Suspension of cocaine plus repeated Tα1 administrations strongly restored NK activity and, interestingly, spleen cells from mice treated with Tα1 during and after cocaine administration achieved a very rapid recovery and the greatest stimulation of natural cytotoxicity. This last treatment also restored the cocaine-inhibited specific T-cell response (i.e. allogeneic cytotoxic T-lymphocyte (CTL) generation) and abrograted the cocaine-induced suppression of interferon gamma (IFN-γ), interleukin 2 (IL-2) and IL-4 production. Finally restoration and induction of thymic cellularity were significant when Tα1 was given during and after cocaine administration. The present investigation provides evidence for the first time that thymic hormones could be of potential value in controlling cocaine-induced impairment of T-cell-mediated immunity in the mouse.
| Original language | English |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | International Journal of Immunopharmacology |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Immunology
- Pharmacology
Cite this
Thymosin alpha one restores murine T-cell-mediated responses inhibited by In vivo cocaine administration. / Di Francesco, Paolo; Pica, Francesca; Marini, Stefano; Favalli, Cartesio; Garaci, Enrico.
In: International Journal of Immunopharmacology, Vol. 14, No. 1, 1992, p. 1-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thymosin alpha one restores murine T-cell-mediated responses inhibited by In vivo cocaine administration
AU - Di Francesco, Paolo
AU - Pica, Francesca
AU - Marini, Stefano
AU - Favalli, Cartesio
AU - Garaci, Enrico
PY - 1992
Y1 - 1992
N2 - The effects of different in vivo thymosin alpha one (Tα1) treatments on T-cell responses inhibited by cocaine abuse were studied. Administration during cocaine treatment promoted a faster recovery of normal natural killer (NK) cell activity after the suspension of abuse. Suspension of cocaine plus repeated Tα1 administrations strongly restored NK activity and, interestingly, spleen cells from mice treated with Tα1 during and after cocaine administration achieved a very rapid recovery and the greatest stimulation of natural cytotoxicity. This last treatment also restored the cocaine-inhibited specific T-cell response (i.e. allogeneic cytotoxic T-lymphocyte (CTL) generation) and abrograted the cocaine-induced suppression of interferon gamma (IFN-γ), interleukin 2 (IL-2) and IL-4 production. Finally restoration and induction of thymic cellularity were significant when Tα1 was given during and after cocaine administration. The present investigation provides evidence for the first time that thymic hormones could be of potential value in controlling cocaine-induced impairment of T-cell-mediated immunity in the mouse.
AB - The effects of different in vivo thymosin alpha one (Tα1) treatments on T-cell responses inhibited by cocaine abuse were studied. Administration during cocaine treatment promoted a faster recovery of normal natural killer (NK) cell activity after the suspension of abuse. Suspension of cocaine plus repeated Tα1 administrations strongly restored NK activity and, interestingly, spleen cells from mice treated with Tα1 during and after cocaine administration achieved a very rapid recovery and the greatest stimulation of natural cytotoxicity. This last treatment also restored the cocaine-inhibited specific T-cell response (i.e. allogeneic cytotoxic T-lymphocyte (CTL) generation) and abrograted the cocaine-induced suppression of interferon gamma (IFN-γ), interleukin 2 (IL-2) and IL-4 production. Finally restoration and induction of thymic cellularity were significant when Tα1 was given during and after cocaine administration. The present investigation provides evidence for the first time that thymic hormones could be of potential value in controlling cocaine-induced impairment of T-cell-mediated immunity in the mouse.
UR - http://www.scopus.com/inward/record.url?scp=0026556643&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026556643&partnerID=8YFLogxK
U2 - 10.1016/0192-0561(92)90098-6
DO - 10.1016/0192-0561(92)90098-6
M3 - Article
C2 - 1582729
AN - SCOPUS:0026556643
VL - 14
SP - 1
EP - 9
JO - International Journal of Immunopharmacology
JF - International Journal of Immunopharmacology
SN - 0192-0561
IS - 1
ER -