Thymostimulin treatment in AIDS-related complex

Lucia Palmisano; Teodoro Chisesi; Massimo Galli; Francesco M. Gritti; Giuseppe Ielasi; Adriano Lazzarin; Ivano Mezzaroma; Mauro Moroni; Enzo Raise; Alberto Vaglia; Fernando Aiuti

doi:10.1016/S0090-1229(88)80003-5

Thymostimulin treatment in AIDS-related complex

Lucia Palmisano, Teodoro Chisesi, Massimo Galli, Francesco M. Gritti, Giuseppe Ielasi, Adriano Lazzarin, Ivano Mezzaroma, Mauro Moroni, Enzo Raise, Alberto Vaglia, Fernando Aiuti

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

Thirty-four patients with AIDS-related complex (ARC) were treated for 6 months with thymostimulin, a thymic hormone. Clinical and immunological findings after a 1-year follow-up were compared with those in 24 age- and sex-matched controls receiving no immunotherapy. Statistical evaluation after 6 and 12 months showed significant differences in the two groups. The thymostimulin-treated group had higher leukocyte and lymphocyte counts, more positivity in intradermal tests with multiple recall antigens, and less lymphadenopathy and weight loss. The number of OKT3+ and OKT4+ lymphocytes decreased significantly in the control group, but did not change in the thymostimulin-treated patients. Finally, after 18 months of follow-up, no progression to AIDS was seen among the treated subjects, whereas 3 of the controls developed the disease. We conclude that thymostimulin, alone or in combination with antiviral drugs, may be helpful in the management of ARC patients.

Original language	English
Pages (from-to)	253-261
Number of pages	9
Journal	Clinical Immunology and Immunopathology
Volume	47
Issue number	3
DOIs	https://doi.org/10.1016/S0090-1229(88)80003-5
Publication status	Published - 1988

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ASJC Scopus subject areas

Immunology
Immunology and Allergy
Pathology and Forensic Medicine

Cite this

Palmisano, L., Chisesi, T., Galli, M., Gritti, F. M., Ielasi, G., Lazzarin, A., Mezzaroma, I., Moroni, M., Raise, E., Vaglia, A., & Aiuti, F. (1988). Thymostimulin treatment in AIDS-related complex. Clinical Immunology and Immunopathology, 47(3), 253-261. https://doi.org/10.1016/S0090-1229(88)80003-5

Thymostimulin treatment in AIDS-related complex. / Palmisano, Lucia; Chisesi, Teodoro; Galli, Massimo; Gritti, Francesco M.; Ielasi, Giuseppe; Lazzarin, Adriano; Mezzaroma, Ivano; Moroni, Mauro; Raise, Enzo; Vaglia, Alberto; Aiuti, Fernando.

In: Clinical Immunology and Immunopathology, Vol. 47, No. 3, 1988, p. 253-261.

Research output: Contribution to journal › Article

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10.1016/S0090-1229(88)80003-5