Thymostimulin treatment in AIDS-related complex

Lucia Palmisano, Teodoro Chisesi, Massimo Galli, Francesco M. Gritti, Giuseppe Ielasi, Adriano Lazzarin, Ivano Mezzaroma, Mauro Moroni, Enzo Raise, Alberto Vaglia, Fernando Aiuti

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Abstract

Thirty-four patients with AIDS-related complex (ARC) were treated for 6 months with thymostimulin, a thymic hormone. Clinical and immunological findings after a 1-year follow-up were compared with those in 24 age- and sex-matched controls receiving no immunotherapy. Statistical evaluation after 6 and 12 months showed significant differences in the two groups. The thymostimulin-treated group had higher leukocyte and lymphocyte counts, more positivity in intradermal tests with multiple recall antigens, and less lymphadenopathy and weight loss. The number of OKT3+ and OKT4+ lymphocytes decreased significantly in the control group, but did not change in the thymostimulin-treated patients. Finally, after 18 months of follow-up, no progression to AIDS was seen among the treated subjects, whereas 3 of the controls developed the disease. We conclude that thymostimulin, alone or in combination with antiviral drugs, may be helpful in the management of ARC patients.

Original languageEnglish
Pages (from-to)253-261
Number of pages9
JournalClinical Immunology and Immunopathology
Volume47
Issue number3
DOIs
Publication statusPublished - 1988

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ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Palmisano, L., Chisesi, T., Galli, M., Gritti, F. M., Ielasi, G., Lazzarin, A., Mezzaroma, I., Moroni, M., Raise, E., Vaglia, A., & Aiuti, F. (1988). Thymostimulin treatment in AIDS-related complex. Clinical Immunology and Immunopathology, 47(3), 253-261. https://doi.org/10.1016/S0090-1229(88)80003-5