Thymus tuberculosis poorly responding to anti-mycobacterial therapy in a young girl with primary infection

Oliviero Sacco, Claudio Gambini, Marco Aicardi, Michela Silvestri, Umberto G. Rossi, Paolo Tomà, Girolamo Mattioli, Vincenzo Jasonni, Giovanni A. Rossi

Research output: Contribution to journalArticle

Abstract

Tuberculous infection of the thymus is a rare condition, previously described only in young adults. A case of a young girl with primary pulmonary tuberculosis, hilar and mediastinal lymph node enlargement and a partially necrotic mass in antero-superior mediastinum is described. Treatment with three anti-mycobacterial drugs was started, effective in markedly reducing all the intrathoracic abnormalities with the exception of the antero-superior mediastinal mass. Since the radiographic and ultrasonographic appearance of the thymus tuberculous infection may be indistinguishable from other serious conditions, including lymphoma and thymoma, a diagnostic procedure was performed. Evaluation of the resected specimen showed foci of caseation and multiple granulomas with extensive central necrosis within the thymic tissue.

Original languageEnglish
Pages (from-to)232-236
Number of pages5
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Volume21
Issue number3
Publication statusPublished - Oct 2004

Keywords

  • Childhood
  • Thymus
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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