Abstract
Objective: A retrospective study to evaluate the changes in TSH concentrations in diabetic patients treated or not treated with metformin and/or L-thyroxine (L-T4). Methods: Three hundred and ninety three euthyroid diabetic patients were divided into three groups on the basis of metformin and/or L-T4 treatment: Group (M-/L-), 119 subjects never treated with metformin and L-T4; Group (M+/L-), 203 subjects who started metformin treatment at recruitment; and Group (M+/L+), 71 patients on L-T4 who started metformin recruitment. Results: The effect of metformin on serum TSH concentrations was analyzed in relation to the basal value of TSH (below 2.5 mIU/l (Q1) or between 2.51 and 4.5 mIU/l (Q2)). In patients of group M+/L+, TSH significantly decreased independently from the basal level (Q1, from 1.45±0.53 to 1.01±1.12 mU/l (P=0.037); Q2, from 3.60±0.53 to 1.91±0.89 mU/l (P
| Original language | English |
|---|---|
| Pages (from-to) | 261-265 |
| Number of pages | 5 |
| Journal | European Journal of Endocrinology |
| Volume | 167 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 2012 |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Thyreotropin levels in diabetic patients on metformin treatment. / Cappelli, Carlo; Rotondi, Mario; Pirola, Ilenia; Agosti, Barbara; Formenti, Annamaria; Zarra, Emanuela; Valentini, Umberto; Leporati, Paola; Chiovato, Luca; Castellano, Maurizio.
In: European Journal of Endocrinology, Vol. 167, No. 2, 08.2012, p. 261-265.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thyreotropin levels in diabetic patients on metformin treatment
AU - Cappelli, Carlo
AU - Rotondi, Mario
AU - Pirola, Ilenia
AU - Agosti, Barbara
AU - Formenti, Annamaria
AU - Zarra, Emanuela
AU - Valentini, Umberto
AU - Leporati, Paola
AU - Chiovato, Luca
AU - Castellano, Maurizio
PY - 2012/8
Y1 - 2012/8
N2 - Objective: A retrospective study to evaluate the changes in TSH concentrations in diabetic patients treated or not treated with metformin and/or L-thyroxine (L-T4). Methods: Three hundred and ninety three euthyroid diabetic patients were divided into three groups on the basis of metformin and/or L-T4 treatment: Group (M-/L-), 119 subjects never treated with metformin and L-T4; Group (M+/L-), 203 subjects who started metformin treatment at recruitment; and Group (M+/L+), 71 patients on L-T4 who started metformin recruitment. Results: The effect of metformin on serum TSH concentrations was analyzed in relation to the basal value of TSH (below 2.5 mIU/l (Q1) or between 2.51 and 4.5 mIU/l (Q2)). In patients of group M+/L+, TSH significantly decreased independently from the basal level (Q1, from 1.45±0.53 to 1.01±1.12 mU/l (P=0.037); Q2, from 3.60±0.53 to 1.91±0.89 mU/l (P
AB - Objective: A retrospective study to evaluate the changes in TSH concentrations in diabetic patients treated or not treated with metformin and/or L-thyroxine (L-T4). Methods: Three hundred and ninety three euthyroid diabetic patients were divided into three groups on the basis of metformin and/or L-T4 treatment: Group (M-/L-), 119 subjects never treated with metformin and L-T4; Group (M+/L-), 203 subjects who started metformin treatment at recruitment; and Group (M+/L+), 71 patients on L-T4 who started metformin recruitment. Results: The effect of metformin on serum TSH concentrations was analyzed in relation to the basal value of TSH (below 2.5 mIU/l (Q1) or between 2.51 and 4.5 mIU/l (Q2)). In patients of group M+/L+, TSH significantly decreased independently from the basal level (Q1, from 1.45±0.53 to 1.01±1.12 mU/l (P=0.037); Q2, from 3.60±0.53 to 1.91±0.89 mU/l (P
UR - http://www.scopus.com/inward/record.url?scp=84864369553&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864369553&partnerID=8YFLogxK
U2 - 10.1530/EJE-12-0225
DO - 10.1530/EJE-12-0225
M3 - Article
C2 - 22645202
AN - SCOPUS:84864369553
VL - 167
SP - 261
EP - 265
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 2
ER -