Thyreotropin levels in diabetic patients on metformin treatment

Carlo Cappelli, Mario Rotondi, Ilenia Pirola, Barbara Agosti, Annamaria Formenti, Emanuela Zarra, Umberto Valentini, Paola Leporati, Luca Chiovato, Maurizio Castellano

Research output: Contribution to journalArticlepeer-review


Objective: A retrospective study to evaluate the changes in TSH concentrations in diabetic patients treated or not treated with metformin and/or L-thyroxine (L-T4). Methods: Three hundred and ninety three euthyroid diabetic patients were divided into three groups on the basis of metformin and/or L-T4 treatment: Group (M-/L-), 119 subjects never treated with metformin and L-T4; Group (M+/L-), 203 subjects who started metformin treatment at recruitment; and Group (M+/L+), 71 patients on L-T4 who started metformin recruitment. Results: The effect of metformin on serum TSH concentrations was analyzed in relation to the basal value of TSH (below 2.5 mIU/l (Q1) or between 2.51 and 4.5 mIU/l (Q2)). In patients of group M+/L+, TSH significantly decreased independently from the basal level (Q1, from 1.45±0.53 to 1.01±1.12 mU/l (P=0.037); Q2, from 3.60±0.53 to 1.91±0.89 mU/l (P

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalEuropean Journal of Endocrinology
Issue number2
Publication statusPublished - Aug 2012

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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