Thyreotropin levels in diabetic patients on metformin treatment

Carlo Cappelli; Mario Rotondi; Ilenia Pirola; Barbara Agosti; Annamaria Formenti; Emanuela Zarra; Umberto Valentini; Paola Leporati; Luca Chiovato; Maurizio Castellano

doi:10.1530/EJE-12-0225

Thyreotropin levels in diabetic patients on metformin treatment

Carlo Cappelli, Mario Rotondi, Ilenia Pirola, Barbara Agosti, Annamaria Formenti, Emanuela Zarra, Umberto Valentini, Paola Leporati, Luca Chiovato, Maurizio Castellano

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article

Abstract

Objective: A retrospective study to evaluate the changes in TSH concentrations in diabetic patients treated or not treated with metformin and/or L-thyroxine (L-T4). Methods: Three hundred and ninety three euthyroid diabetic patients were divided into three groups on the basis of metformin and/or L-T4 treatment: Group (M-/L-), 119 subjects never treated with metformin and L-T4; Group (M+/L-), 203 subjects who started metformin treatment at recruitment; and Group (M+/L+), 71 patients on L-T4 who started metformin recruitment. Results: The effect of metformin on serum TSH concentrations was analyzed in relation to the basal value of TSH (below 2.5 mIU/l (Q1) or between 2.51 and 4.5 mIU/l (Q2)). In patients of group M+/L+, TSH significantly decreased independently from the basal level (Q1, from 1.45±0.53 to 1.01±1.12 mU/l (P=0.037); Q2, from 3.60±0.53 to 1.91±0.89 mU/l (P

Original language	English
Pages (from-to)	261-265
Number of pages	5
Journal	European Journal of Endocrinology
Volume	167
Issue number	2
DOIs	https://doi.org/10.1530/EJE-12-0225
Publication status	Published - Aug 2012

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ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

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Cappelli, C., Rotondi, M., Pirola, I., Agosti, B., Formenti, A., Zarra, E., Valentini, U., Leporati, P., Chiovato, L., & Castellano, M. (2012). Thyreotropin levels in diabetic patients on metformin treatment. European Journal of Endocrinology, 167(2), 261-265. https://doi.org/10.1530/EJE-12-0225

Thyreotropin levels in diabetic patients on metformin treatment. / Cappelli, Carlo; Rotondi, Mario; Pirola, Ilenia; Agosti, Barbara; Formenti, Annamaria; Zarra, Emanuela; Valentini, Umberto; Leporati, Paola; Chiovato, Luca; Castellano, Maurizio.

In: European Journal of Endocrinology, Vol. 167, No. 2, 08.2012, p. 261-265.

Research output: Contribution to journal › Article

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