Thyreotropin levels in diabetic patients on metformin treatment

Carlo Cappelli, Mario Rotondi, Ilenia Pirola, Barbara Agosti, Annamaria Formenti, Emanuela Zarra, Umberto Valentini, Paola Leporati, Luca Chiovato, Maurizio Castellano

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Abstract

Objective: A retrospective study to evaluate the changes in TSH concentrations in diabetic patients treated or not treated with metformin and/or L-thyroxine (L-T4). Methods: Three hundred and ninety three euthyroid diabetic patients were divided into three groups on the basis of metformin and/or L-T4 treatment: Group (M-/L-), 119 subjects never treated with metformin and L-T4; Group (M+/L-), 203 subjects who started metformin treatment at recruitment; and Group (M+/L+), 71 patients on L-T4 who started metformin recruitment. Results: The effect of metformin on serum TSH concentrations was analyzed in relation to the basal value of TSH (below 2.5 mIU/l (Q1) or between 2.51 and 4.5 mIU/l (Q2)). In patients of group M+/L+, TSH significantly decreased independently from the basal level (Q1, from 1.45±0.53 to 1.01±1.12 mU/l (P=0.037); Q2, from 3.60±0.53 to 1.91±0.89 mU/l (P

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalEuropean Journal of Endocrinology
Volume167
Issue number2
DOIs
Publication statusPublished - Aug 2012

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Metformin
Thyrotropin
Therapeutics
Thyroxine
Retrospective Studies
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Cappelli, C., Rotondi, M., Pirola, I., Agosti, B., Formenti, A., Zarra, E., ... Castellano, M. (2012). Thyreotropin levels in diabetic patients on metformin treatment. European Journal of Endocrinology, 167(2), 261-265. https://doi.org/10.1530/EJE-12-0225

Thyreotropin levels in diabetic patients on metformin treatment. / Cappelli, Carlo; Rotondi, Mario; Pirola, Ilenia; Agosti, Barbara; Formenti, Annamaria; Zarra, Emanuela; Valentini, Umberto; Leporati, Paola; Chiovato, Luca; Castellano, Maurizio.

In: European Journal of Endocrinology, Vol. 167, No. 2, 08.2012, p. 261-265.

Research output: Contribution to journalArticle

Cappelli, C, Rotondi, M, Pirola, I, Agosti, B, Formenti, A, Zarra, E, Valentini, U, Leporati, P, Chiovato, L & Castellano, M 2012, 'Thyreotropin levels in diabetic patients on metformin treatment', European Journal of Endocrinology, vol. 167, no. 2, pp. 261-265. https://doi.org/10.1530/EJE-12-0225
Cappelli, Carlo ; Rotondi, Mario ; Pirola, Ilenia ; Agosti, Barbara ; Formenti, Annamaria ; Zarra, Emanuela ; Valentini, Umberto ; Leporati, Paola ; Chiovato, Luca ; Castellano, Maurizio. / Thyreotropin levels in diabetic patients on metformin treatment. In: European Journal of Endocrinology. 2012 ; Vol. 167, No. 2. pp. 261-265.
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