Thyroid and other organ-specific autoantibodies in healthy ceritenarians

S. Mariotti, G. Barbesino, P. Caturegli, T. Giacomelli, A. Pinchera, D. Monti, A. Cossarizza, C. Franceschi, P. Sansoni, G. Passeri, U. Fagiolo

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Abstract

To investigate the prevalence of thyroid autoantibodies in very old subjects, we assayed sera from 34 healthy centenarians (7 men, 27 women; age range 100-108 years) for these antibodies. There was a clear age-dependent increase in prevalence of thyroid autoantibodies in sera from 549 control subjects aged 7-85 years, prevalence in 40 subjects aged 70-85 being significantly greater (p2) than that in 436 subjects aged less than 50. By contrast, prevalence of thyroid autoantibodies in centenarians was not significantly different from that in controls aged less than 50. Cytofluorimetric analysis of peripheral blood lymphocytes showed a striking age-dependent decrease in total and CD5+ B cells (without changes in their ratio), which reached its nadir in centenarians. The age-dependent increase in prevalence of thyroid autoantibodies in the elderly is not seen after the ninth decade of life. What relation this characteristic has to derangement of circulating B cells is unknown. Lancet 1992; 339: 1506-08.

Original languageEnglish
Pages (from-to)1506-1508
Number of pages3
JournalLancet
Volume339
Issue number8808
DOIs
Publication statusPublished - Jun 20 1992

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ASJC Scopus subject areas

  • Medicine(all)

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Mariotti, S., Barbesino, G., Caturegli, P., Giacomelli, T., Pinchera, A., Monti, D., Cossarizza, A., Franceschi, C., Sansoni, P., Passeri, G., & Fagiolo, U. (1992). Thyroid and other organ-specific autoantibodies in healthy ceritenarians. Lancet, 339(8808), 1506-1508. https://doi.org/10.1016/0140-6736(92)91265-A