Thyroid autoimmunity in children with coeliac disease: A prospective survey

Antonella Diamanti, Francesca Ferretti, Rinaldo Guglielmi, Fabio Panetta, Franco Colistro, Marco Cappa, Antonella Daniele, Maria Sole Basso, Cristian Noto, Massimo Crisogianni, Massimo Castro

Research output: Contribution to journalArticlepeer-review


Background: Thyroid autoimmunity (TA) is often associated with coeliac disease (CD). Objective: To evaluate, in children and adolescents with CD on a gluten-free diet (GFD): (1) the prevalence of TA; (2) the impact of TA on growth and the need for L-thyroxine (L-T4) treatment, during a longitudinal survey. Method: Between January and December 2005, 545 patients with CD, prospectively followed up until December 2007, and 622 controls were screened for TA. Antithyroperoxidase and antithyroglobulin antibodies were assayed and, if positive, serum free tri-iodothyronine, free thyroxine and thyroid-stimulating hormone (TSH) assays and thyroid ultrasound were performed. L-T4 was started if TSH was >5.5 mU/ml at two successive measurements. Results: There was no significant difference in TA prevalence between patients with CD on a GFD (10%) and controls (8.2%). Duration of GFD differed significantly in coeliac patients with TA in comparison with those without TA (7.9±0.9 and 10.2±0.3 years, p

Original languageEnglish
Pages (from-to)1038-1041
Number of pages4
JournalArchives of Disease in Childhood
Issue number11
Publication statusPublished - Nov 2011

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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