Abstract
Background: Thyroid autoimmunity (TA) is often associated with coeliac disease (CD). Objective: To evaluate, in children and adolescents with CD on a gluten-free diet (GFD): (1) the prevalence of TA; (2) the impact of TA on growth and the need for L-thyroxine (L-T4) treatment, during a longitudinal survey. Method: Between January and December 2005, 545 patients with CD, prospectively followed up until December 2007, and 622 controls were screened for TA. Antithyroperoxidase and antithyroglobulin antibodies were assayed and, if positive, serum free tri-iodothyronine, free thyroxine and thyroid-stimulating hormone (TSH) assays and thyroid ultrasound were performed. L-T4 was started if TSH was >5.5 mU/ml at two successive measurements. Results: There was no significant difference in TA prevalence between patients with CD on a GFD (10%) and controls (8.2%). Duration of GFD differed significantly in coeliac patients with TA in comparison with those without TA (7.9±0.9 and 10.2±0.3 years, p
| Original language | English |
|---|---|
| Pages (from-to) | 1038-1041 |
| Number of pages | 4 |
| Journal | Archives of Disease in Childhood |
| Volume | 96 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2011 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Thyroid autoimmunity in children with coeliac disease : A prospective survey. / Diamanti, Antonella; Ferretti, Francesca; Guglielmi, Rinaldo; Panetta, Fabio; Colistro, Franco; Cappa, Marco; Daniele, Antonella; Basso, Maria Sole; Noto, Cristian; Crisogianni, Massimo; Castro, Massimo.
In: Archives of Disease in Childhood, Vol. 96, No. 11, 11.2011, p. 1038-1041.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thyroid autoimmunity in children with coeliac disease
T2 - A prospective survey
AU - Diamanti, Antonella
AU - Ferretti, Francesca
AU - Guglielmi, Rinaldo
AU - Panetta, Fabio
AU - Colistro, Franco
AU - Cappa, Marco
AU - Daniele, Antonella
AU - Basso, Maria Sole
AU - Noto, Cristian
AU - Crisogianni, Massimo
AU - Castro, Massimo
PY - 2011/11
Y1 - 2011/11
N2 - Background: Thyroid autoimmunity (TA) is often associated with coeliac disease (CD). Objective: To evaluate, in children and adolescents with CD on a gluten-free diet (GFD): (1) the prevalence of TA; (2) the impact of TA on growth and the need for L-thyroxine (L-T4) treatment, during a longitudinal survey. Method: Between January and December 2005, 545 patients with CD, prospectively followed up until December 2007, and 622 controls were screened for TA. Antithyroperoxidase and antithyroglobulin antibodies were assayed and, if positive, serum free tri-iodothyronine, free thyroxine and thyroid-stimulating hormone (TSH) assays and thyroid ultrasound were performed. L-T4 was started if TSH was >5.5 mU/ml at two successive measurements. Results: There was no significant difference in TA prevalence between patients with CD on a GFD (10%) and controls (8.2%). Duration of GFD differed significantly in coeliac patients with TA in comparison with those without TA (7.9±0.9 and 10.2±0.3 years, p
AB - Background: Thyroid autoimmunity (TA) is often associated with coeliac disease (CD). Objective: To evaluate, in children and adolescents with CD on a gluten-free diet (GFD): (1) the prevalence of TA; (2) the impact of TA on growth and the need for L-thyroxine (L-T4) treatment, during a longitudinal survey. Method: Between January and December 2005, 545 patients with CD, prospectively followed up until December 2007, and 622 controls were screened for TA. Antithyroperoxidase and antithyroglobulin antibodies were assayed and, if positive, serum free tri-iodothyronine, free thyroxine and thyroid-stimulating hormone (TSH) assays and thyroid ultrasound were performed. L-T4 was started if TSH was >5.5 mU/ml at two successive measurements. Results: There was no significant difference in TA prevalence between patients with CD on a GFD (10%) and controls (8.2%). Duration of GFD differed significantly in coeliac patients with TA in comparison with those without TA (7.9±0.9 and 10.2±0.3 years, p
UR - http://www.scopus.com/inward/record.url?scp=80054719812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054719812&partnerID=8YFLogxK
U2 - 10.1136/archdischild-2011-300595
DO - 10.1136/archdischild-2011-300595
M3 - Article
C2 - 21862521
AN - SCOPUS:80054719812
VL - 96
SP - 1038
EP - 1041
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
SN - 0003-9888
IS - 11
ER -