Thyroid C-cell hyperplasia shown by combined in-111 pentetreotide, Tc-99m pertechnetate, and Tc-99m MIBI scintigraphy

Diego Cecchin, Franco Lumachi, Filippo Marino, Roberto Stramare, Umberto Basso, Gaia Grassetto, Franco Bui

Research output: Contribution to journalArticlepeer-review

Abstract

A patient with a previous diagnosis of colorectal adenocarcinoma presented with increased chromogranin A. In-111 pentetreotide whole body scan revealed an area of intense homogeneous uptake in the right thyroid lobe. A "cold" area, corresponding to the nodule was detected by Tc-99m pertechnetate thyroid scintigraphy (PTS). Two US-guided FNA biopsies indicated that the lesion was benign, whereas it appeared to have a malignant potential in functional imaging studies. Tc-99m Sestamibi thyroid scintigraphy was indicative of cellularity increasing the likelihood of malignancy. Calcitonin-specific stain on the removed nodule revealed some strongly-stained parafollicular elements. Final diagnosis was neoplastic C-cell hyperplasia, which is thought to precede sporadic medullary thyroid carcinoma.

Original languageEnglish
Pages (from-to)378-379
Number of pages2
JournalClinical Nuclear Medicine
Volume32
Issue number5
DOIs
Publication statusPublished - May 2007

Keywords

  • C-cell Hyperplasia
  • In-111 pentetreotide
  • Tc-99m MIBI
  • Tc-99m pertechnetate
  • Thyroid scintigraphy
  • Thyroid tumors

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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