Thyroid Cancer

Angela Greco, Claudia Miranda, Maria Grazia Borrello, Marco A. Pierotti

Research output: Chapter in Book/Report/Conference proceedingChapter


Thyroid cancer represents the most common endocrine malignancy and its incidence is increasing. The majority of thyroid tumours (90-95%) originate from the follicular epithelial cells; it includes several histotypes and related variants characterized by different biological and clinical behavior, such as differentiated papillary and follicular carcinoma (PTC and FTC), and poorly differentiated and anaplastic carcinoma (PDTC and ATC). Medullary thyroid carcinoma (MTC) represents a small fraction of thyroid tumors and originates from the parafollicular C cells. PTCs feature a frequent deregulation of the MAPK pathway, as RET/PTC, TRK, RAS or BRAF oncogenes have been found in about 70% of cases. FTCs are associated with RAS mutations and PAX8/PPARγ oncogenic chromosome rearrangements. PDTCs and ATCs display some alterations occurring in differentiated tumors, as well as other alterations specific of late tumor stages. MTC carry RET or RAS mutations. Here we summarize the molecular alterations detected in each thyroid tumor type, their role in the process of thyroid carcinogenesis, as well as how high-throughput gene expression analyses have contributed to the study of this malignancy.

Original languageEnglish
Title of host publicationCancer Genomics: From Bench to Personalized Medicine
PublisherElsevier Inc.
Number of pages16
ISBN (Print)9780123969675
Publication statusPublished - Dec 2013


  • ALK
  • ATC
  • BRAF
  • FTC
  • Gene rearrangement
  • MTC
  • NTRK1
  • Oncogenes
  • PDTC
  • PI3K
  • PTC
  • RAS
  • RET

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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