Thyroid carcinoma in children and adolescents

D. Danese, A. Gardini, A. Farsetti, S. Sciacchitano, M. Andreoli, A. Pontecorvi

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

A clinical and pathological study was undertaken to define the prevalence, clinical presentation and outcome of thyroid carcinoma in children and adolescents. Clinical records from 48 patients under 20 years of age at diagnosis, out of 372 patients with thyroid cancer examined between 1980 and 1994, were retrospectively reviewed. Female/male ratio was 3.8/1. None had a previous positive history of head and neck irradiation. Patients underwent near-total (44 patients) or partial (4 patients) thyroidectomy followed by 131I ablation of residual thyroid tissue. The mean follow up period was 58.4 months ranging between 2 and 190 months. Clinically a thyroid mass was present in 41 patients, 28 of whom also showed neck lymph node involvement. Node metastases were present in 50% of the patients and lung metastases in 4.2%. Histological type was papillary in 41, follicular in 6, and medullary in 1 case. Surgical complications were observed in 19 patients (40%). In 3 patients papillary thyroid cancer was associated with chronic lymphocytic thyroiditis. All patients were treated with 1-thyroxine suppressive therapy. Recurrence of cancer after surgical and radio-iodine treatment was observed only in one patient 8 months after surgery. Conclusion. Our experience demonstrates that thyroid carcinoma in childhood cannot be considered a rare occurrence, since it represents about 13% of all thyroid cancers, and is frequently associated with lymph node but rarely with distant metastases. Nevertheless, the prognosis of thyroid carcinoma in childhood is fairly good.

Original languageEnglish
Pages (from-to)190-194
Number of pages5
JournalEuropean Journal of Pediatrics
Volume156
Issue number3
DOIs
Publication statusPublished - 1997

Fingerprint

Thyroid Neoplasms
Neoplasm Metastasis
Thyroid Gland
Neck
Lymph Nodes
Hashimoto Disease
Thyroidectomy
Radio
Thyroxine
Iodine
Head
Recurrence
Lung

Keywords

  • Childhood
  • Epidemiology
  • Thyroid cancer
  • Thyroid gland

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Danese, D., Gardini, A., Farsetti, A., Sciacchitano, S., Andreoli, M., & Pontecorvi, A. (1997). Thyroid carcinoma in children and adolescents. European Journal of Pediatrics, 156(3), 190-194. https://doi.org/10.1007/s004310050580

Thyroid carcinoma in children and adolescents. / Danese, D.; Gardini, A.; Farsetti, A.; Sciacchitano, S.; Andreoli, M.; Pontecorvi, A.

In: European Journal of Pediatrics, Vol. 156, No. 3, 1997, p. 190-194.

Research output: Contribution to journalArticle

Danese, D, Gardini, A, Farsetti, A, Sciacchitano, S, Andreoli, M & Pontecorvi, A 1997, 'Thyroid carcinoma in children and adolescents', European Journal of Pediatrics, vol. 156, no. 3, pp. 190-194. https://doi.org/10.1007/s004310050580
Danese D, Gardini A, Farsetti A, Sciacchitano S, Andreoli M, Pontecorvi A. Thyroid carcinoma in children and adolescents. European Journal of Pediatrics. 1997;156(3):190-194. https://doi.org/10.1007/s004310050580
Danese, D. ; Gardini, A. ; Farsetti, A. ; Sciacchitano, S. ; Andreoli, M. ; Pontecorvi, A. / Thyroid carcinoma in children and adolescents. In: European Journal of Pediatrics. 1997 ; Vol. 156, No. 3. pp. 190-194.
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