Thyroid disease

Alfredo Rebora, Franco Rongioletti

Research output: Chapter in Book/Report/Conference proceedingChapter


Dermatological manifestations as a sign of thyroid disturbances occur either in thyreotoxic states or in the evolution of autoimmune diseases of the thyroid that is in apparent euthyroidism, or in overt hypothyroidism. Pretibial myxedema and thyroid acropachy are typical manifestations of hyperthyroidism, in particular of Graves' disease. Vitiligo, diffuse alopecia (both telogen effluvium and alopecia areata), and chronic urticaria can be associated with autoimmune disease of the thyroid. Generalized myxedema is the most common skin manifestation of hypothyroidism characterized by yellowish, cold, and dry skin filled with mucin, nonpitting edema of face and extremities, dry and brittle hairs, resulting in diffuse or partial alopecia. In generalized myxedema, skin symptoms subside with thyroxine administration, while treatment of pretibial myxedema and thyroid acropachy remains problematic.

Original languageEnglish
Title of host publicationClinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional and Deposition Disease
PublisherSpringer New York
Number of pages7
ISBN (Print)9781607611806
Publication statusPublished - 2010


  • Generalized myxedema
  • Hyperthyroidism
  • Hypothyroidism
  • Pretibial myxedema
  • Thyroid acropachy

ASJC Scopus subject areas

  • Medicine(all)


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