Thyroid disorders in patients treated with radiotherapy for head-and-neck cancer

A retrospective analysis of seventy-three patients

Daniela Alterio, Barbara Alicja Jereczek-Fossa, Benedetta Franchi, Alberto D'Onofrio, Valeria Piazzi, Elena Rondi, Mario Ciocca, Bianca Gibelli, Enrica Grosso, Nicoletta Tradati, Luigi Mariani, Genoveva Ionela Boboc, Roberto Orecchia

Research output: Contribution to journalArticle

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Abstract

Purpose: To evaluate the incidence of thyroid disorders and dose distribution to the thyroid in patients treated with radiotherapy for head-and-neck carcinomas. Methods and Materials: A retrospective evaluation of data from 73 patients treated for head-and-neck cancers in our department was performed. Thyroid function was evaluated mainly by the measurement of thyrotropin (thyroid stimulating hormone [TSH]). A retrospective analysis of treatment plans was performed for 57 patients. Percentages of thyroid glandular volume absorbing 10, 30, and 50 Gy (V10, V30, and V50 respectively) were considered for statistical analysis. Results: A majority of patients (61%) had a normal thyroid function whereas 19 patients (26%) had hypothyroidism. Mean thyroid volume was 30.39 cc. Point 3 (located at isthmus) absorbed lower doses compared with other points (p <0.0001). Median values of V10, V30, and V50 were 92% (range, 57-100%), 75% (range, 28.5-100%), and 35% (range, 3-83%) respectively. Gender was associated with toxicity (presence of any kind of thyroid disorders) (p <0.05), with females displaying higher levels of TSHr (relative TSH = patient's value/maximum value of the laboratory range) (p = 0.0005) and smaller thyroid volume (p = 0.0012) compared with male population. TSHr values were associated with thyroid volume, and the presence of midline shielding block in the anterior field was associated with relative free thyroxine (FT4r = patient's value/maximum value of the laboratory range) values. Conclusions: Gender and thyroid volume seem to play an important role in the occurrence of thyroid toxicity, but further studies on dose-effect relationship for radiotherapy-induced thyroid toxicity are needed.

Original languageEnglish
Pages (from-to)144-150
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Volume67
Issue number1
DOIs
Publication statusPublished - Jan 1 2007

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Head and Neck Neoplasms
radiation therapy
Thyroid Gland
Radiotherapy
cancer
disorders
toxicity
hormones
dosage
Thyrotropin
isthmuses
thyroxine
statistical analysis
shielding
incidence
occurrences
Hypothyroidism
Thyroxine
evaluation
Neck

Keywords

  • Cancer
  • Radiotherapy
  • Thyroid disorders

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Thyroid disorders in patients treated with radiotherapy for head-and-neck cancer : A retrospective analysis of seventy-three patients. / Alterio, Daniela; Jereczek-Fossa, Barbara Alicja; Franchi, Benedetta; D'Onofrio, Alberto; Piazzi, Valeria; Rondi, Elena; Ciocca, Mario; Gibelli, Bianca; Grosso, Enrica; Tradati, Nicoletta; Mariani, Luigi; Boboc, Genoveva Ionela; Orecchia, Roberto.

In: International Journal of Radiation Oncology Biology Physics, Vol. 67, No. 1, 01.01.2007, p. 144-150.

Research output: Contribution to journalArticle

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T1 - Thyroid disorders in patients treated with radiotherapy for head-and-neck cancer

T2 - A retrospective analysis of seventy-three patients

AU - Alterio, Daniela

AU - Jereczek-Fossa, Barbara Alicja

AU - Franchi, Benedetta

AU - D'Onofrio, Alberto

AU - Piazzi, Valeria

AU - Rondi, Elena

AU - Ciocca, Mario

AU - Gibelli, Bianca

AU - Grosso, Enrica

AU - Tradati, Nicoletta

AU - Mariani, Luigi

AU - Boboc, Genoveva Ionela

AU - Orecchia, Roberto

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N2 - Purpose: To evaluate the incidence of thyroid disorders and dose distribution to the thyroid in patients treated with radiotherapy for head-and-neck carcinomas. Methods and Materials: A retrospective evaluation of data from 73 patients treated for head-and-neck cancers in our department was performed. Thyroid function was evaluated mainly by the measurement of thyrotropin (thyroid stimulating hormone [TSH]). A retrospective analysis of treatment plans was performed for 57 patients. Percentages of thyroid glandular volume absorbing 10, 30, and 50 Gy (V10, V30, and V50 respectively) were considered for statistical analysis. Results: A majority of patients (61%) had a normal thyroid function whereas 19 patients (26%) had hypothyroidism. Mean thyroid volume was 30.39 cc. Point 3 (located at isthmus) absorbed lower doses compared with other points (p <0.0001). Median values of V10, V30, and V50 were 92% (range, 57-100%), 75% (range, 28.5-100%), and 35% (range, 3-83%) respectively. Gender was associated with toxicity (presence of any kind of thyroid disorders) (p <0.05), with females displaying higher levels of TSHr (relative TSH = patient's value/maximum value of the laboratory range) (p = 0.0005) and smaller thyroid volume (p = 0.0012) compared with male population. TSHr values were associated with thyroid volume, and the presence of midline shielding block in the anterior field was associated with relative free thyroxine (FT4r = patient's value/maximum value of the laboratory range) values. Conclusions: Gender and thyroid volume seem to play an important role in the occurrence of thyroid toxicity, but further studies on dose-effect relationship for radiotherapy-induced thyroid toxicity are needed.

AB - Purpose: To evaluate the incidence of thyroid disorders and dose distribution to the thyroid in patients treated with radiotherapy for head-and-neck carcinomas. Methods and Materials: A retrospective evaluation of data from 73 patients treated for head-and-neck cancers in our department was performed. Thyroid function was evaluated mainly by the measurement of thyrotropin (thyroid stimulating hormone [TSH]). A retrospective analysis of treatment plans was performed for 57 patients. Percentages of thyroid glandular volume absorbing 10, 30, and 50 Gy (V10, V30, and V50 respectively) were considered for statistical analysis. Results: A majority of patients (61%) had a normal thyroid function whereas 19 patients (26%) had hypothyroidism. Mean thyroid volume was 30.39 cc. Point 3 (located at isthmus) absorbed lower doses compared with other points (p <0.0001). Median values of V10, V30, and V50 were 92% (range, 57-100%), 75% (range, 28.5-100%), and 35% (range, 3-83%) respectively. Gender was associated with toxicity (presence of any kind of thyroid disorders) (p <0.05), with females displaying higher levels of TSHr (relative TSH = patient's value/maximum value of the laboratory range) (p = 0.0005) and smaller thyroid volume (p = 0.0012) compared with male population. TSHr values were associated with thyroid volume, and the presence of midline shielding block in the anterior field was associated with relative free thyroxine (FT4r = patient's value/maximum value of the laboratory range) values. Conclusions: Gender and thyroid volume seem to play an important role in the occurrence of thyroid toxicity, but further studies on dose-effect relationship for radiotherapy-induced thyroid toxicity are needed.

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KW - Radiotherapy

KW - Thyroid disorders

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