Thyroid dysfunction in women with systemic sclerosis

Bianca Marasini, Pier Alda Ferrari, Nadia Solaro, Carlo Selmi

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Hypothyroidism has been frequently reported in systemic sclerosis (SSc), but whether SSc itself increases the risk of thyroid dysfunction is still controversial. The aim of the present study was to determine whether routine thyroid function screening in SSc should be warranted. Serum levels of free triiodothyronine, free thyroxine, and thyroid-stimulating hormone, and the presence of thyroid-specific autoantibodies (antithyroid peroxidase and antithyreoglobulin) were measured in 79 women with SSc and 81 age-matched women with osteoarthritis (OA) serving as controls. Hyperthyroidismwas found in 2 of 79 (2.5%) SSc and in 4 of 81 (5%) OA cases. Hypothyroidism was found in 16 of 79 (20%) patients with SSc (subclinical in 14/16 cases) and in 9 of 81 (11%) patients with OA (subclinical in all cases; P = 0.131). Antithyreoglobulin antibodies were present in 14% versus 13% patients (SSc versus OA, P = NS), whereas antithyroid peroxidase antibodies were present in 23% versus 11% patients (SSc versusOA, P = 0.057). The risk of hypothyroidism was significantly higher in antithyroid peroxidase-positive patients (P <0.0001), irrespective of the primary diagnosis, and greater in women with OA (OR = 24.6, 95% CI 4.3-141.9, P <0.0001) than SSc (OR = 4.2, 95% CI 1.2-14.3, P = 0.035). SSc is not independently associated with an increased risk of thyroid dysfunction, but antithyroid peroxidase antibodies may identify a subset of patients at risk of developing thyroid dysfunction.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages7
Publication statusPublished - Jun 2007

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • Hypothyroidism
  • Scleroderma
  • Thyroid autoantibodies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Thyroid dysfunction in women with systemic sclerosis'. Together they form a unique fingerprint.

Cite this