TY - JOUR
T1 - Thyroid hormone and affective disorders
AU - Liappas, Ioannis
AU - Drago, Antonio
AU - Zisakis, Athanasios K.
AU - Malitas, Petros N.
AU - Zisaki, Aikaterini K.
AU - Kalofoutis, Anastasios
AU - Lea, Robert W.
AU - Pantos, Konstantinos
AU - Serretti, Alessandro
PY - 2009
Y1 - 2009
N2 - Thyroid hormones are necessary to the brain development and their absence results into serious cognitive defects. There is some evidence that thyroid hormones' activity is required in the adult brain for a correct neuronal net orchestration as well. The bonds between mood disorders and thyroid imbalances are reviewed in this paper, the molecular background of these poorly defined boundaries is exposed, along with the putative mechanisms that underlie the antidepressant effect of thyroid hormones in the event of augmentation strategy.
AB - Thyroid hormones are necessary to the brain development and their absence results into serious cognitive defects. There is some evidence that thyroid hormones' activity is required in the adult brain for a correct neuronal net orchestration as well. The bonds between mood disorders and thyroid imbalances are reviewed in this paper, the molecular background of these poorly defined boundaries is exposed, along with the putative mechanisms that underlie the antidepressant effect of thyroid hormones in the event of augmentation strategy.
KW - Cognitive defects
KW - Mood disorders
KW - Thyroid hormones
UR - http://www.scopus.com/inward/record.url?scp=68249138927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68249138927&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:68249138927
VL - 6
SP - 103
EP - 111
JO - Clinical Neuropsychiatry
JF - Clinical Neuropsychiatry
SN - 1724-4935
IS - 3
ER -