Thyroid hormone and affective disorders

Ioannis Liappas; Antonio Drago; Athanasios K. Zisakis; Petros N. Malitas; Aikaterini K. Zisaki; Anastasios Kalofoutis; Robert W. Lea; Konstantinos Pantos; Alessandro Serretti

Thyroid hormone and affective disorders

Ioannis Liappas, Antonio Drago, Athanasios K. Zisakis, Petros N. Malitas, Aikaterini K. Zisaki, Anastasios Kalofoutis, Robert W. Lea, Konstantinos Pantos, Alessandro Serretti

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article › peer-review

Abstract

Thyroid hormones are necessary to the brain development and their absence results into serious cognitive defects. There is some evidence that thyroid hormones' activity is required in the adult brain for a correct neuronal net orchestration as well. The bonds between mood disorders and thyroid imbalances are reviewed in this paper, the molecular background of these poorly defined boundaries is exposed, along with the putative mechanisms that underlie the antidepressant effect of thyroid hormones in the event of augmentation strategy.

Original language	English
Pages (from-to)	103-111
Number of pages	9
Journal	Clinical Neuropsychiatry
Volume	6
Issue number	3
Publication status	Published - 2009

Keywords

Cognitive defects
Mood disorders
Thyroid hormones

ASJC Scopus subject areas

Psychiatry and Mental health

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AU - Liappas, Ioannis

AU - Drago, Antonio

AU - Zisakis, Athanasios K.

AU - Malitas, Petros N.

AU - Zisaki, Aikaterini K.

AU - Kalofoutis, Anastasios

AU - Lea, Robert W.

AU - Pantos, Konstantinos

AU - Serretti, Alessandro

PY - 2009

Y1 - 2009

N2 - Thyroid hormones are necessary to the brain development and their absence results into serious cognitive defects. There is some evidence that thyroid hormones' activity is required in the adult brain for a correct neuronal net orchestration as well. The bonds between mood disorders and thyroid imbalances are reviewed in this paper, the molecular background of these poorly defined boundaries is exposed, along with the putative mechanisms that underlie the antidepressant effect of thyroid hormones in the event of augmentation strategy.

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KW - Cognitive defects

KW - Mood disorders

KW - Thyroid hormones

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