Thyroid hormone and affective disorders

Ioannis Liappas, Antonio Drago, Athanasios K. Zisakis, Petros N. Malitas, Aikaterini K. Zisaki, Anastasios Kalofoutis, Robert W. Lea, Konstantinos Pantos, Alessandro Serretti

Research output: Contribution to journalArticle

Abstract

Thyroid hormones are necessary to the brain development and their absence results into serious cognitive defects. There is some evidence that thyroid hormones' activity is required in the adult brain for a correct neuronal net orchestration as well. The bonds between mood disorders and thyroid imbalances are reviewed in this paper, the molecular background of these poorly defined boundaries is exposed, along with the putative mechanisms that underlie the antidepressant effect of thyroid hormones in the event of augmentation strategy.

Original languageEnglish
Pages (from-to)103-111
Number of pages9
JournalClinical Neuropsychiatry
Volume6
Issue number3
Publication statusPublished - 2009

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Keywords

  • Cognitive defects
  • Mood disorders
  • Thyroid hormones

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Liappas, I., Drago, A., Zisakis, A. K., Malitas, P. N., Zisaki, A. K., Kalofoutis, A., Lea, R. W., Pantos, K., & Serretti, A. (2009). Thyroid hormone and affective disorders. Clinical Neuropsychiatry, 6(3), 103-111.