TY - CHAP
T1 - Thyroid Hormone and the White Matter of the Central Nervous System
T2 - From Development to Repair
AU - Calzà, Laura
AU - Baldassarro, Vito A.
AU - Fernandez, Mercedes
AU - Giuliani, Alessandro
AU - Lorenzini, Luca
AU - Giardino, Luciana
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The role of thyroid hormone (TH) on brain development, and particularly in myelination, is well known since many decades, as testified by the severe structural and functional consequences of congenital hypothyroidism. This role during development, the consideration that the early TH supplementation restores myelination capability, and the fact the cell responsible for developmental myelination and remyelination is the same, i.e., the oligodendrocyte precursor cell (OPC), claimed the attempt to improve myelin repair in the adulthood via TH supplementation. In this chapter, the impact of TH on development, homeostasis, and repair of the myelin in the CNS will be reviewed, focusing on the regulation of the TH tissue signaling during physiological and pathological conditions affecting myelination and/or myelin repair during early postnatal age and during the adulthood. The impact of the tissue inflammation on molecular mediators of the TH cellular action and metabolism will be discussed, with regard to the consequences on the biology of the OPC.
AB - The role of thyroid hormone (TH) on brain development, and particularly in myelination, is well known since many decades, as testified by the severe structural and functional consequences of congenital hypothyroidism. This role during development, the consideration that the early TH supplementation restores myelination capability, and the fact the cell responsible for developmental myelination and remyelination is the same, i.e., the oligodendrocyte precursor cell (OPC), claimed the attempt to improve myelin repair in the adulthood via TH supplementation. In this chapter, the impact of TH on development, homeostasis, and repair of the myelin in the CNS will be reviewed, focusing on the regulation of the TH tissue signaling during physiological and pathological conditions affecting myelination and/or myelin repair during early postnatal age and during the adulthood. The impact of the tissue inflammation on molecular mediators of the TH cellular action and metabolism will be discussed, with regard to the consequences on the biology of the OPC.
KW - Deiodinases
KW - Inflammation
KW - Myelination
KW - Nonthyroidal illness syndrome
KW - Oligodendrocyte precursor cells
KW - Remyelination
KW - Thyroid hormone receptors
UR - http://www.scopus.com/inward/record.url?scp=85020447422&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020447422&partnerID=8YFLogxK
U2 - 10.1016/bs.vh.2017.04.003
DO - 10.1016/bs.vh.2017.04.003
M3 - Chapter
C2 - 29407438
AN - SCOPUS:85020447422
T3 - Vitamins and Hormones
SP - 253
EP - 281
BT - Vitamins and Hormones
A2 - Litwack, Gerald
PB - Academic Press Inc.
ER -