Thyroid Hormone and the White Matter of the Central Nervous System: From Development to Repair

Laura Calzà, Vito A. Baldassarro, Mercedes Fernandez, Alessandro Giuliani, Luca Lorenzini, Luciana Giardino

Research output: Chapter in Book/Report/Conference proceedingChapter


The role of thyroid hormone (TH) on brain development, and particularly in myelination, is well known since many decades, as testified by the severe structural and functional consequences of congenital hypothyroidism. This role during development, the consideration that the early TH supplementation restores myelination capability, and the fact the cell responsible for developmental myelination and remyelination is the same, i.e., the oligodendrocyte precursor cell (OPC), claimed the attempt to improve myelin repair in the adulthood via TH supplementation. In this chapter, the impact of TH on development, homeostasis, and repair of the myelin in the CNS will be reviewed, focusing on the regulation of the TH tissue signaling during physiological and pathological conditions affecting myelination and/or myelin repair during early postnatal age and during the adulthood. The impact of the tissue inflammation on molecular mediators of the TH cellular action and metabolism will be discussed, with regard to the consequences on the biology of the OPC.

Original languageEnglish
Title of host publicationVitamins and Hormones
EditorsGerald Litwack
PublisherAcademic Press Inc.
Number of pages29
Publication statusPublished - Jan 1 2018

Publication series

NameVitamins and Hormones
ISSN (Print)0083-6729


  • Deiodinases
  • Inflammation
  • Myelination
  • Nonthyroidal illness syndrome
  • Oligodendrocyte precursor cells
  • Remyelination
  • Thyroid hormone receptors

ASJC Scopus subject areas

  • Physiology
  • Endocrinology


Dive into the research topics of 'Thyroid Hormone and the White Matter of the Central Nervous System: From Development to Repair'. Together they form a unique fingerprint.

Cite this