Thyroid hormone as a regulator of tumor induced angiogenesis

Marta Pinto, Paula Soares, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

Thyroid hormones (TH) - 3,5,3′-triiodo-l-thyronine (T3) and l-thyroxine (T4) - are important regulators of differentiation, growth, metabolism, and physiological function in most tissues. TH have been also implicated in cellular transformation, tumorigenesis and metastasis, assuming particular importance in tumor induced angiogenesis. TH-induced angiogenesis is thought to be initiated at integrin αvβ3 membrane receptor mainly through T4 binding. The reduction of TH in circulation or the inhibition of TH actions at the integrin αvβ3 receptor would consequently produce a reduction on the proliferative and angiogenic TH effects. Therefore, targeting TH actions could be an alternative adjuvant therapy against cancer proliferation and angiogenesis.

Original languageEnglish
Pages (from-to)119-126
Number of pages8
JournalCancer Letters
Volume301
Issue number2
DOIs
Publication statusPublished - Feb 28 2011

Keywords

  • Angiogenesis
  • Anti-angiogenesis
  • Thyroid hormones
  • Tumor growth

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Thyroid hormone as a regulator of tumor induced angiogenesis'. Together they form a unique fingerprint.

Cite this