Thyroid hormones and the cardiovascular system: Pathophysiology and interventions

G. Cini, A. Carpi, J. Mechanick, L. Cini, M. Camici, F. Galetta, R. Giardino, M. A. Russo, G. Iervasi

Research output: Contribution to journalArticle

Abstract

Thyroid dysfunction, however mild, can significantly affect the cardiovascular (CV) system. The effects of thyroid hormones may be viewed as genomic and non-genomic, with the former occurring over a longer time scale and both affecting structural and functional proteins in CV tissue. As the interplay between thyroid function and the CV system becomes elucidated, particularly in the context of a system biology approach, the heart failure phenotype is better understood. Symptomatology is related to disturbance in inotropic and chronotropic function. Moreover, biochemical changes reflected by thyroid function testing with the non-thyroidal illness syndrome can prognosticate and guide therapy in heart failure. In addition, empiric treatment with thyroid hormone analogues or T3 represent emergent and highly controversial interventions.

Original languageEnglish
Pages (from-to)742-753
Number of pages12
JournalBiomedicine and Pharmacotherapy
Volume63
Issue number10
DOIs
Publication statusPublished - Dec 2009

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Thyroid hormones and the cardiovascular system: Pathophysiology and interventions'. Together they form a unique fingerprint.

  • Cite this

    Cini, G., Carpi, A., Mechanick, J., Cini, L., Camici, M., Galetta, F., Giardino, R., Russo, M. A., & Iervasi, G. (2009). Thyroid hormones and the cardiovascular system: Pathophysiology and interventions. Biomedicine and Pharmacotherapy, 63(10), 742-753. https://doi.org/10.1016/j.biopha.2009.08.003