Thyroid hormones and the cardiovascular system: Pathophysiology and interventions

G. Cini; A. Carpi; J. Mechanick; L. Cini; M. Camici; F. Galetta; R. Giardino; M. A. Russo; G. Iervasi

doi:10.1016/j.biopha.2009.08.003

Thyroid hormones and the cardiovascular system: Pathophysiology and interventions

G. Cini, A. Carpi, J. Mechanick, L. Cini, M. Camici, F. Galetta, R. Giardino, M. A. Russo, G. Iervasi

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article

Abstract

Thyroid dysfunction, however mild, can significantly affect the cardiovascular (CV) system. The effects of thyroid hormones may be viewed as genomic and non-genomic, with the former occurring over a longer time scale and both affecting structural and functional proteins in CV tissue. As the interplay between thyroid function and the CV system becomes elucidated, particularly in the context of a system biology approach, the heart failure phenotype is better understood. Symptomatology is related to disturbance in inotropic and chronotropic function. Moreover, biochemical changes reflected by thyroid function testing with the non-thyroidal illness syndrome can prognosticate and guide therapy in heart failure. In addition, empiric treatment with thyroid hormone analogues or T3 represent emergent and highly controversial interventions.

Original language	English
Pages (from-to)	742-753
Number of pages	12
Journal	Biomedicine and Pharmacotherapy
Volume	63
Issue number	10
DOIs	https://doi.org/10.1016/j.biopha.2009.08.003
Publication status	Published - Dec 2009

ASJC Scopus subject areas

Pharmacology

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Cini, G., Carpi, A., Mechanick, J., Cini, L., Camici, M., Galetta, F., Giardino, R., Russo, M. A., & Iervasi, G. (2009). Thyroid hormones and the cardiovascular system: Pathophysiology and interventions. Biomedicine and Pharmacotherapy, 63(10), 742-753. https://doi.org/10.1016/j.biopha.2009.08.003

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AU - Russo, M. A.

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