Thyroid hormones and their metabolites: Biological roles and association with non-alcoholic fatty liver disease

Davide Gnocchi, Anna Alisi, Giovannella Bruscalupi

Research output: Contribution to journalArticle

Abstract

Thyroid hormones (THs) and their metabolites are potent regulators of energy and lipid metabolism in the liver. Besides the physiological role of THs in liver cell homeostasis, thyroid dysfunctions have been shown to play an essential part in the onset and progression of some liver diseases. Among these, non-alcoholic fatty liver disease (NAFLD), the current leading reason of development of chronic liver diseases worldwide, has emerged. In the present review, we analyse the main biological activities of THs and of some of their metabolites, along with their mechanisms of action, focusing on their role as master regulators of energy metabolism. We describe the relationship between thyroid dysfunctions and the development of NAFLD. Finally, we underline how the study of THs and their metabolites might be useful to develop new therapeutic approaches for NAFLD.

Original languageEnglish
Pages (from-to)43-59
Number of pages17
JournalImmunology, Endocrine and Metabolic Agents in Medicinal Chemistry
Volume15
Issue number1
Publication statusPublished - Jul 1 2015

Keywords

  • Diodothyronines
  • Hyperthyroidism
  • Hypothyroidism
  • Lipid lowering
  • NAFLD
  • Thyroid hormones

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Pharmacology

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