Abstract
The aim of the present review was to summarize knowledge about thyroid hormones (THs) and longevity. Longevity is a complex multifactorial phenomenon on which specific biological pathways, including hormonal networks involved in the regulation of homeostasis and survival, exert a strong impact. THs are the key responsible for growth, metabolism rate and energy expenditure, and help in maintaining cognition, bone and cardiovascular health. THs production and metabolism are fine tuned, and may help the organism to cope with a variety of environmental challenges. Experimental evidence suggests that hypothyroid state may favor longevity by reducing metabolism rate, oxidative stress and cell senescence. Data from human studies involving healthy subjects and centenarians seem to confirm this view, but THs changes observed in older patients affected by chronic diseases cannot be always interpreted as a protective adaptive mechanism aimed at reducing catabolism and prolonging survival. Medications, selected chronic diseases and multi-morbidity can interfere with thyroid function, and their impact is still to be elucidated.
| Original language | English |
|---|---|
| Pages (from-to) | 98-106 |
| Number of pages | 9 |
| Journal | Mechanisms of Ageing and Development |
| Volume | 165 |
| DOIs | |
| Publication status | Published - Jul 1 2017 |
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Keywords
- Age-related diseases
- Aging
- Centenarians
- Longevity
- Thyroid
ASJC Scopus subject areas
- Ageing
- Developmental Biology
Cite this
Thyroid hormones in extreme longevity. / Garasto, Sabrina; Montesanto, Alberto; Corsonello, Andrea; Lattanzio, Fabrizia; Fusco, Sergio; Passarino, Giuseppe; Prestipino Giarritta, Valeria; Corica, Francesco.
In: Mechanisms of Ageing and Development, Vol. 165, 01.07.2017, p. 98-106.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Thyroid hormones in extreme longevity
AU - Garasto, Sabrina
AU - Montesanto, Alberto
AU - Corsonello, Andrea
AU - Lattanzio, Fabrizia
AU - Fusco, Sergio
AU - Passarino, Giuseppe
AU - Prestipino Giarritta, Valeria
AU - Corica, Francesco
PY - 2017/7/1
Y1 - 2017/7/1
N2 - The aim of the present review was to summarize knowledge about thyroid hormones (THs) and longevity. Longevity is a complex multifactorial phenomenon on which specific biological pathways, including hormonal networks involved in the regulation of homeostasis and survival, exert a strong impact. THs are the key responsible for growth, metabolism rate and energy expenditure, and help in maintaining cognition, bone and cardiovascular health. THs production and metabolism are fine tuned, and may help the organism to cope with a variety of environmental challenges. Experimental evidence suggests that hypothyroid state may favor longevity by reducing metabolism rate, oxidative stress and cell senescence. Data from human studies involving healthy subjects and centenarians seem to confirm this view, but THs changes observed in older patients affected by chronic diseases cannot be always interpreted as a protective adaptive mechanism aimed at reducing catabolism and prolonging survival. Medications, selected chronic diseases and multi-morbidity can interfere with thyroid function, and their impact is still to be elucidated.
AB - The aim of the present review was to summarize knowledge about thyroid hormones (THs) and longevity. Longevity is a complex multifactorial phenomenon on which specific biological pathways, including hormonal networks involved in the regulation of homeostasis and survival, exert a strong impact. THs are the key responsible for growth, metabolism rate and energy expenditure, and help in maintaining cognition, bone and cardiovascular health. THs production and metabolism are fine tuned, and may help the organism to cope with a variety of environmental challenges. Experimental evidence suggests that hypothyroid state may favor longevity by reducing metabolism rate, oxidative stress and cell senescence. Data from human studies involving healthy subjects and centenarians seem to confirm this view, but THs changes observed in older patients affected by chronic diseases cannot be always interpreted as a protective adaptive mechanism aimed at reducing catabolism and prolonging survival. Medications, selected chronic diseases and multi-morbidity can interfere with thyroid function, and their impact is still to be elucidated.
KW - Age-related diseases
KW - Aging
KW - Centenarians
KW - Longevity
KW - Thyroid
UR - http://www.scopus.com/inward/record.url?scp=85016011724&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85016011724&partnerID=8YFLogxK
U2 - 10.1016/j.mad.2017.03.002
DO - 10.1016/j.mad.2017.03.002
M3 - Review article
AN - SCOPUS:85016011724
VL - 165
SP - 98
EP - 106
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
ER -