Thyroid hormones in extreme longevity

Sabrina Garasto, Alberto Montesanto, Andrea Corsonello, Fabrizia Lattanzio, Sergio Fusco, Giuseppe Passarino, Valeria Prestipino Giarritta, Francesco Corica

Research output: Contribution to journalReview articlepeer-review


The aim of the present review was to summarize knowledge about thyroid hormones (THs) and longevity. Longevity is a complex multifactorial phenomenon on which specific biological pathways, including hormonal networks involved in the regulation of homeostasis and survival, exert a strong impact. THs are the key responsible for growth, metabolism rate and energy expenditure, and help in maintaining cognition, bone and cardiovascular health. THs production and metabolism are fine tuned, and may help the organism to cope with a variety of environmental challenges. Experimental evidence suggests that hypothyroid state may favor longevity by reducing metabolism rate, oxidative stress and cell senescence. Data from human studies involving healthy subjects and centenarians seem to confirm this view, but THs changes observed in older patients affected by chronic diseases cannot be always interpreted as a protective adaptive mechanism aimed at reducing catabolism and prolonging survival. Medications, selected chronic diseases and multi-morbidity can interfere with thyroid function, and their impact is still to be elucidated.

Original languageEnglish
Pages (from-to)98-106
Number of pages9
JournalMechanisms of Ageing and Development
Publication statusPublished - Jul 1 2017


  • Age-related diseases
  • Aging
  • Centenarians
  • Longevity
  • Thyroid

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology


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