Thyroid hypoechogenic pattern at ultrasonography as a tool for predicting recurrence of hyperthyroidism after medical treatment in patients with Graves' disease

P. Vitti, T. Rago, F. Mancusi, S. Pallini, M. Tonacchera, F. Santini, L. Chiovato, C. Marcocci, A. Pinchera

Research output: Contribution to journalArticlepeer-review

Abstract

An abnormal thyroid echographic pattern characterized by a diffuse low echogenicity has been described in Hashimoto's thyroiditis and Graves' disease. The aim of the present work was to study the relationship between thyroid hypoechogenicity and the outcome of treatment for hyperthyroidism with antithyroid drugs in patients with Graves' disease. The study group included 105 patients who underwent a course of methimazole treatment. Thyroid ultrasonography was carried out at diagnosis, and autoantibodies to thyrotropin receptor (TK-ab) were measured at the end of treatment. During the follow-up after methimazole treatment, 87/105 (83%) patients had relapse of hyperthyroidism and 18/105 (17%) were in remission. Recurrence or hyperthyroidism occurred in 71/76 (93%) patients with thyroid hypoechogenicity and in 16/29 (55%) of those with normal thyroid echogenicity (χ2=19.0; p2=10.9; p2=9.8; p

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalActa Endocrinologica
Volume126
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Endocrinology

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