Thyroid remnant estimation by Tc-99m-sestamibi scanning predicts the effectiveness of rhTSH-stimulated I-131 ablation in patients with differentiated thyroid carcinoma

Luca Giovanella, Sergio Suriano, Massimo Castellani, Luca Ceriani, Frederik A. Verburg

Research output: Contribution to journalArticle

Abstract

AIM: To evaluate the relationship between postsurgical cervical Tc-99m-sestamibi scan uptake and the rate of successful remnant ablation after recombinant human-thyrotropin (rhTSH)-aided-I-131 ablation in patients with differentiated thyroid carcinoma (DTC). METHODS: In all, 154 DTC patients who underwent total thyroidectomy and rhTSH-aided remnant ablation with I-131 (3.7 GBq) were enrolled. Tc-99m-sestamibi scans were performed during continuing thyroid hormone administration in all cases. Thyroid ablation was assessed after 6 to 12 months by rhTSH-stimulated I-131-whole-body scan and thyroglobulin measurement. The rate of successful ablation, occurrence of radioiodine-induced thyroiditis, and length of hospitalization were correlated with the Tc-99m-sestamibi scintigraphy results. RESULTS: Tc-99m-sestamibi uptake was significantly lower in ablated versus nonablated patients (P <0.0001). A visually positive scan and a Tc-99m-sestamibi uptake greater than 0.9% predicted a high-risk of unsuccessful ablation, prolonged hospitalization, and the occurrence of radioiodine-induced thyroiditis. CONCLUSIONS: Tc-99m-sestamibi scintigraphy is a simple and feasible tool to evaluate thyroid remnants and to predict radioiodine ablation results in patients with DTC.

Original languageEnglish
Pages (from-to)781-785
Number of pages5
JournalClinical Nuclear Medicine
Volume36
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • differentiated thyroid carcinoma
  • radioiodine
  • Tc-99m-sestamibi
  • total thyroidectomy
  • whole-body scan

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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