Thyroid Stimulating Hormone Secreting Tumor

Andrea Lania, Luca Persani, Paolo Beck-Peccoz

Research output: Chapter in Book/Report/Conference proceedingChapter


Thyroid stimulating hormone (TSH)-secreting pituitary adenomas (TSH-omas) are rare disorders causing central hyperthyroidism, a condition characterized by high levels of free thyroxin (T4) and free triiodothyronine (T3) in the presence of measurable TSH concentrations. Failure to identify the presence of TSH-omas may result in an improper thyroid ablation which may lead to a significant increase of tumor mass. The diagnosis is mainly achieved by measuring TSH after T3 suppression and TRH stimulation tests, these dynamic tests being useful in distinguishing TSH-omas from syndromes of resistance to thyroid hormone action (RTH). The treatment of choice is surgery. If surgery fails, somatostatin analogs have been found to be effective in normalizing TSH secretion in more than 90% of patients.

Original languageEnglish
Title of host publicationPituitary Disorders: Diagnosis and Management
Number of pages8
ISBN (Print)9780470672013
Publication statusPublished - Mar 8 2013


  • Central hyperthyroidism
  • Somatostatin analogues
  • Thyrotropin(TSH)
  • Transphenoidal surgery
  • TSH-secreting pituitary adenoma

ASJC Scopus subject areas

  • Medicine(all)


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