Thyroid-stimulating hormone, thyroglobulin, and thyroid hormones and risk of differentiated thyroid carcinoma: The EPIC study

Sabina Rinaldi, Martyn Plummer, Carine Biessy, Konstantinos K. Tsilidis, Jane Nautrup Ostergaard, Kim Overvad, Anne Tjonneland, Jytte Halkjær, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Laure Dossus, Rudolf Kaaks, Annekatrin Lukanova, Heiner Boeing, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Claudia Agnoli, Rosario TuminoPaolo Vineis, Salvatore Panico, H. Bas Bueno De-Mesquita, Petra H. Peeters, Elisabete Weiderpass, Eiliv Lund, J. Ramón Quirós, Antonio Agudo, Esther Molina, Nerea Larrañaga, Carmen Navarro, Eva Ardanaz, Jonas Manjer, Martin Almquist, Maria Sandström, Joakim Hennings, Kay Tee Khaw, Julie Schmidt, Ruth C. Travis, Graham Byrnes, Augustin Scalbert, Isabelle Romieu, Marc Gunter, Elio Riboli, Silvia Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

Background Increased levels of thyroglobulin (Tg) and thyroid-stimulating hormone (TSH) are associated with differentiated thyroid carcinoma (TC) risk, but strong epidemiological evidence is lacking. Methods Three hundred fifty-seven incident TC case patients (n = 300 women and 57 men; mean age at blood collection = 51.5 years) were identified in the EPIC cohort study and matched with 2 (women) or 3 (men) control subjects using incidence density sampling. Matching included study center, sex, age, date, time, and fasting status at blood collection. Levels of total and free (f) thyroxine (T4) and triiodo-thyronine (T3), TSH, Tg, and anti-Tg antibodies (TgAb) were measured by commercially available immunoassays. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using conditional logistic regression. All statistical tests were two-sided. Results TC risk was positively associated with Tg (OR for the highest vs lowest quartile = 9.15; 95% CI = 5.28 to 15.90; P

Original languageEnglish
JournalJournal of the National Cancer Institute
Volume106
Issue number6
DOIs
Publication statusPublished - Jun 11 2014

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Thyroid-stimulating hormone, thyroglobulin, and thyroid hormones and risk of differentiated thyroid carcinoma: The EPIC study'. Together they form a unique fingerprint.

Cite this