TY - JOUR
T1 - Thyroid-stimulating hormone, thyroglobulin, and thyroid hormones and risk of differentiated thyroid carcinoma
T2 - The EPIC study
AU - Rinaldi, Sabina
AU - Plummer, Martyn
AU - Biessy, Carine
AU - Tsilidis, Konstantinos K.
AU - Ostergaard, Jane Nautrup
AU - Overvad, Kim
AU - Tjonneland, Anne
AU - Halkjær, Jytte
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Françoise
AU - Dossus, Laure
AU - Kaaks, Rudolf
AU - Lukanova, Annekatrin
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Trichopoulos, Dimitrios
AU - Palli, Domenico
AU - Agnoli, Claudia
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Panico, Salvatore
AU - De-Mesquita, H. Bas Bueno
AU - Peeters, Petra H.
AU - Weiderpass, Elisabete
AU - Lund, Eiliv
AU - Quirós, J. Ramón
AU - Agudo, Antonio
AU - Molina, Esther
AU - Larrañaga, Nerea
AU - Navarro, Carmen
AU - Ardanaz, Eva
AU - Manjer, Jonas
AU - Almquist, Martin
AU - Sandström, Maria
AU - Hennings, Joakim
AU - Khaw, Kay Tee
AU - Schmidt, Julie
AU - Travis, Ruth C.
AU - Byrnes, Graham
AU - Scalbert, Augustin
AU - Romieu, Isabelle
AU - Gunter, Marc
AU - Riboli, Elio
AU - Franceschi, Silvia
PY - 2014/6/11
Y1 - 2014/6/11
N2 - Background Increased levels of thyroglobulin (Tg) and thyroid-stimulating hormone (TSH) are associated with differentiated thyroid carcinoma (TC) risk, but strong epidemiological evidence is lacking. Methods Three hundred fifty-seven incident TC case patients (n = 300 women and 57 men; mean age at blood collection = 51.5 years) were identified in the EPIC cohort study and matched with 2 (women) or 3 (men) control subjects using incidence density sampling. Matching included study center, sex, age, date, time, and fasting status at blood collection. Levels of total and free (f) thyroxine (T4) and triiodo-thyronine (T3), TSH, Tg, and anti-Tg antibodies (TgAb) were measured by commercially available immunoassays. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using conditional logistic regression. All statistical tests were two-sided. Results TC risk was positively associated with Tg (OR for the highest vs lowest quartile = 9.15; 95% CI = 5.28 to 15.90; P
AB - Background Increased levels of thyroglobulin (Tg) and thyroid-stimulating hormone (TSH) are associated with differentiated thyroid carcinoma (TC) risk, but strong epidemiological evidence is lacking. Methods Three hundred fifty-seven incident TC case patients (n = 300 women and 57 men; mean age at blood collection = 51.5 years) were identified in the EPIC cohort study and matched with 2 (women) or 3 (men) control subjects using incidence density sampling. Matching included study center, sex, age, date, time, and fasting status at blood collection. Levels of total and free (f) thyroxine (T4) and triiodo-thyronine (T3), TSH, Tg, and anti-Tg antibodies (TgAb) were measured by commercially available immunoassays. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using conditional logistic regression. All statistical tests were two-sided. Results TC risk was positively associated with Tg (OR for the highest vs lowest quartile = 9.15; 95% CI = 5.28 to 15.90; P
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U2 - 10.1093/jnci/dju097
DO - 10.1093/jnci/dju097
M3 - Article
C2 - 24824312
AN - SCOPUS:84905188724
VL - 106
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 6
ER -