Thyroid ultrasonography as a tool for detecting thyroid autoimmune diseases and predicting thyroid dysfunction in apparently healthy subjects

T. Rago, L. Chiovato, L. Grasso, A. Pinchera, P. Vitti

Research output: Contribution to journalArticle

Abstract

In order to establish its usefulness for the diagnosis and follow-up of thyroid autoimmune diseases, thyroid ultrasonography together with free T4 (FT4), free T3 (FT3), TSH, antibodies (Tg Ab) and thyroperoxidase antibodies (TPO Ab) were performed and re-evaluated during a 3-yr follow-up in 482 apparently healthy subjects, living in a borderline iodine-sufficient urban area. Thyroid dysfunction was found in 7 out of 12 (58.3%) subjects with circulating thyroid autoantibodies, who also had thyroid hypoechogenicity (2 had overt and 3 subclinical hypothyroidism at booking; 2 developed subclinical hypothyroidism during the follow-up), and in none of the 12 subjects with normal thyroid echostructure (x2=7.26, p=0.007). Thyroid dysfunction was found in 4 out of 29 (13.7%) subjects with negative Tg and/or TPO Ab who also had thyroid hypoechogenicity (1 had Graves' disease at booking, 1 developed Graves' disease and 2 subclinical hypothyroidism during the follow-up), and in none of the 429 with normal thyroid echostructure (x2=82.03, p2=69.66, p

Original languageEnglish
Pages (from-to)763-769
Number of pages7
JournalJournal of Endocrinological Investigation
Volume24
Issue number10
Publication statusPublished - 2001

Keywords

  • Autoimmune thyroid disease
  • Hyperthyroidism
  • Hypothyroidism
  • Thyroid ultrasonography

ASJC Scopus subject areas

  • Endocrinology

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