Thyrotropin values in patients with micropapillary thyroid cancer versus benign nodular disease

Roberto Negro, Roberto Valcavi, Fabrizio Riganti, Konstantinos Toulis, Ermenegildo Colosimo, Massimo Bongiovanni, Pierangela Grassi, Luca Giovanella, Giorgio Gardini, Simonetta Piana

Research output: Contribution to journalArticlepeer-review


Objective: Studies published in the last few years suggest that increased thyroid-stimulating hormone (TSH) values are associated with increased risk of thyroid cancer and/or a more advanced stage of malignancy. The aim of this study was to explore the hypothesis that TSH may be a risk factor for thyroid cancer initiation, which was tested by comparing TSH concentrations in patients with incidental micro papillary cancer (mPTC) and controls with a negative histologic exam.Methods: Patients were retrospectively selected from medical records from 3 district hospitals. Patients with biochemical/histologic evidence of autoimmunity, thyroid function-interfering drugs, and autonomously functioning areas, were excluded. TSH values of 41 patients with an incidental mPTC were then compared with a sex-and age-matched group of patients who had a negative histologic exam at a 4:1 ratio (164 patients).Results: TSH was not significantly different in the mPTC group compared to the controls (1.1 ± 0.7 vs. 1.3 ± 1.0 mIU/L). After adjustment for age and gender, TSH levels were still not found to be significantly different between groups. In the mPTC group, TSH levels were not found to be a significant predictor of tumor size after adjusting for age and gender (β = 0.035, SE = 0.73, P = .844).Conclusions: On the basis of these results, the hypothesis that TSH is involved in de novo oncogenesis of PTC is not supported.

Original languageEnglish
Pages (from-to)651-655
Number of pages5
JournalEndocrine Practice
Issue number4
Publication statusPublished - Jul 1 2013

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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