TY - JOUR
T1 - Thyrotropinomas
AU - Beck-Peccoz, Paolo
AU - Persani, Luca
PY - 2008/3
Y1 - 2008/3
N2 - Thyrotropinomas are easily recognized, owing to the availability of ultrasensitive thyropin immunometric assays. These methods allow a clear distinction between patients who have suppressed and those who have nonsuppressed circulating thyrotropin concentrations. In the latter, it is mandatory to perform a differential diagnosis, as the management of the two disorders is completely different, and failure to recognize the presence of a thyrotropinoma may result in dramatic consequences. Adenomectomy is the firstline treatment of thyrotropinomas, followed by irradiation in the case of surgical failure. Medical treatment with somatostatin analogs is effective in reducing thyrotropin secretion in more than 90% of cases.
AB - Thyrotropinomas are easily recognized, owing to the availability of ultrasensitive thyropin immunometric assays. These methods allow a clear distinction between patients who have suppressed and those who have nonsuppressed circulating thyrotropin concentrations. In the latter, it is mandatory to perform a differential diagnosis, as the management of the two disorders is completely different, and failure to recognize the presence of a thyrotropinoma may result in dramatic consequences. Adenomectomy is the firstline treatment of thyrotropinomas, followed by irradiation in the case of surgical failure. Medical treatment with somatostatin analogs is effective in reducing thyrotropin secretion in more than 90% of cases.
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U2 - 10.1016/j.ecl.2007.10.001
DO - 10.1016/j.ecl.2007.10.001
M3 - Article
C2 - 18226733
AN - SCOPUS:38349156151
VL - 37
SP - 123
EP - 134
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
SN - 0889-8529
IS - 1
ER -