Tiagabine in glial tumors

Salvatore Striano, Pasquale Striano, Patrizia Boccella, Cristofaro Nocerino, Leonilda Bilo

Research output: Contribution to journalArticle

Abstract

Rationale and purpose: Preliminary reports have suggested a possible 'aetiology-specific' efficacy of tiagabine (TGB) in patients with drug-resistant partial epilepsy (DRPE) related to cerebral glial tumors (GTs). This efficacy should be related to selective blocking of GAT-1 transporter by TGB. We presented our open-label, add-on TGB experience in a group of patients with GTs, compared with other symptomatic DRPEs of different aetiology. Material and methods: eleven patients with DRPE related to oligodendroglioma (six cases), astrocytoma (4) or multiform gliobastoma (1); 12 patients with DRPE related to a miscellanea of CNS lesions. TGB was added to previous AEDs, at dosage of 20-60 mg per die. Responders are defined by seizure frequency reduction >50% compared with baseline. Results: Seven patients are responders with three seizure-free (SF) in GTs group, a rate of efficacy much higher than in matching group (63.6 vs. 16.6%). Adverse events have been observed only rarely, not leading to discontinuation, in GTs group. Conclusion: This preliminary observation seems to confirm the high efficacy and tolerability of TGB in DRPE related to GTs.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalEpilepsy Research
Volume49
Issue number1
DOIs
Publication statusPublished - 2002

Keywords

  • Cerebral gliomas
  • Drug resistant epilepsy
  • Tiagabine

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

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    Striano, S., Striano, P., Boccella, P., Nocerino, C., & Bilo, L. (2002). Tiagabine in glial tumors. Epilepsy Research, 49(1), 81-85. https://doi.org/10.1016/S0920-1211(02)00005-0