Tidal breathing affects airway responsiveness to methacholine

Francesco G. Salerno, P. Guido, A. Spanevello

Research output: Contribution to journalArticlepeer-review


Asthma is characterized by increased airway responsiveness and airway inflammation. Airway hyperresponsiveness may be caused by increased airway smooth muscle contractility or by a decrease in the mechanical load that opposes airway smooth muscle contraction. Under static conditions, the equilibrium between contractility and load will determine the final airway smooth muscle length and therefore airway caliber. Because of tidal breathing, however, lungs normally function under dynamic conditions where both airway contractility and opposing load are affected. The capability of tidal breathing to appropriately modulate airway function might be the mechanism that differentiates airways of asthmatics from those of normal subjects.

Original languageEnglish
Pages (from-to)504-507
Number of pages4
JournalMonaldi Archives for Chest Disease - Cardiac Series
Issue number6
Publication statusPublished - 2001


  • Airway responsiveness
  • Airway smooth muscle
  • Asthma
  • Tidal breathing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine


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