Tigecycline lock therapy for catheter-related bloodstream infection caused by KPC-producing Klebsiella pneumoniae in two pediatric hematological patients

Sergio Foresti; Stefano Di Bella; Attilio Rovelli; Alessandra Sala; Marta Verna; Luca Bisi; Carla Nisii; Andrea Gori

doi:10.1128/AAC.01855-15

Tigecycline lock therapy for catheter-related bloodstream infection caused by KPC-producing Klebsiella pneumoniae in two pediatric hematological patients

Sergio Foresti, Stefano Di Bella, Attilio Rovelli, Alessandra Sala, Marta Verna, Luca Bisi, Carla Nisii, Andrea Gori

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Catheter-related bacteremias carry high mortality rates in hematological patients. When a multidrug-resistant microorganism is involved, the catheter should ideally be removed; however, this approach is not always possible. Tigecycline lock therapy was used in two pediatric oncohematological patients with intravascular catheter-related infection due to KPC-producing Klebsiella pneumoniae. The catheter was salvaged in both cases, and the patients were later discharged. Our experience suggests the usefulness of this approach in treating this type of infection.

Original language	English
Pages (from-to)	7919-7920
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	59
Issue number	12
DOIs	https://doi.org/10.1128/AAC.01855-15
Publication status	Published - Dec 1 2015

ASJC Scopus subject areas

Pharmacology (medical)
Pharmacology
Infectious Diseases

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Tigecycline lock therapy for catheter-related bloodstream infection caused by KPC-producing Klebsiella pneumoniae in two pediatric hematological patients. / Foresti, Sergio; Di Bella, Stefano; Rovelli, Attilio; Sala, Alessandra; Verna, Marta; Bisi, Luca; Nisii, Carla; Gori, Andrea.

In: Antimicrobial Agents and Chemotherapy, Vol. 59, No. 12, 01.12.2015, p. 7919-7920.

Research output: Contribution to journal › Article › peer-review

Foresti, Sergio ; Di Bella, Stefano ; Rovelli, Attilio ; Sala, Alessandra ; Verna, Marta ; Bisi, Luca ; Nisii, Carla ; Gori, Andrea. / Tigecycline lock therapy for catheter-related bloodstream infection caused by KPC-producing Klebsiella pneumoniae in two pediatric hematological patients. In: Antimicrobial Agents and Chemotherapy. 2015 ; Vol. 59, No. 12. pp. 7919-7920.

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