Time and diffusion lesion size in major anterior circulation ischemic strokes

Reza Hakimelahi, Behroze A. Vachha, William A. Copen, Giacomo D E Papini, Julian He, Mahmoud M. Higazi, Michael H. Lev, Pamela W. Schaefer, Albert J. Yoo, Lee H. Schwamm, R. Gilberto González

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND PURPOSE -: Major anterior circulation ischemic strokes caused by occlusion of the distal internal carotid artery or proximal middle cerebral artery or both account for about one third of ischemic strokes with mostly poor outcomes. These strokes are treatable by intravenous tissue-type plasminogen activator and endovascular methods. However, dynamics of infarct growth in these strokes are poorly documented. The purpose was to help understand infarct growth dynamics by measuring acute infarct size with diffusion-weighted imaging (DWI) at known times after stroke onset in patients with documented internal carotid artery/middle cerebral artery occlusions. METHODS -: Retrospectively, we included 47 consecutive patients with documented internal carotid artery/middle cerebral artery occlusions who underwent DWI within 30 hours of stroke onset. Prospectively, 139 patients were identified using the same inclusion criteria. DWI lesion volumes were measured and correlated to time since stroke onset. Perfusion data were reviewed in those who underwent perfusion imaging. RESULTS -: Acute infarct volumes ranged from 0.41 to 318.3 mL. Infarct size and time did not correlate (R=0.001). The majority of patients had DWI lesions that were 8 hours after stroke onset. DWI lesions corresponded to areas of greatly reduced perfusion. CONCLUSIONS -: Poor correlation between infarct volume and time after stroke onset suggests that there are factors more powerful than time in determining infarct size within the first 30 hours. The observations suggest that highly variable cerebral perfusion via the collateral circulation may primarily determine infarct growth dynamics. If verified, clinical implications include the possibility of treating many patients outside traditional time windows.

Original languageEnglish
Pages (from-to)2936-2941
Number of pages6
JournalStroke
Volume45
Issue number10
DOIs
Publication statusPublished - Oct 12 2014

    Fingerprint

Keywords

  • brain infarction
  • diffusion
  • magnetic resonance imaging
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Medicine(all)

Cite this

Hakimelahi, R., Vachha, B. A., Copen, W. A., Papini, G. D. E., He, J., Higazi, M. M., Lev, M. H., Schaefer, P. W., Yoo, A. J., Schwamm, L. H., & González, R. G. (2014). Time and diffusion lesion size in major anterior circulation ischemic strokes. Stroke, 45(10), 2936-2941. https://doi.org/10.1161/STROKEAHA.114.005644