This study measured, using ELISA or bioassay methodology, fluctuation in concentration of the circulating cytokines tumor necrosis factor (TNF) and interleukin 6 (IL-6), and the acute phase proteins serum amyloid A (apoSAA) and C-reactive protein (CRP), in five septic patients, during a one-week period starting from the day of diagnosis. All had consistently detectable levels of circulating TNF (range of peak values, 0.6-13.6 ng/ml); two also had high IL-6 levels, while the remaining three had detectable levels only at some time points (range of peak values, 105-315 pg/ ml). TNF concentrations fluctuated during the observation period, in some cases with a biphasic temporal pattern. TNF and IL-6 levels were undetectable (below 30 and 100 pg/ ml, respectively) in the control population with our assays1,2. ApoSAA concentrations in these patients (range of peak values, 65-975 μg/ml) were correlated with TNF and with high CRP concentrations (range of peak values, 7-329 μg/ ml). ApoSAA concentrations ranged from 1 to 10 μg/ml and CRP concentrations ranged from 0.6 to 1.9 μg/ml in control populations with our assay. Statistically significant correlations between TNF levels and both apoSAA and CRP concentrations were observed for the five patients.
|Number of pages||7|
|Publication status||Published - 1997|
- C-reactive protein
- Serum amyloid A
- Tumor necrosis factor
ASJC Scopus subject areas
- Pathology and Forensic Medicine