Abstract
Tebuconazole (TEB) is a fungicide widely used in vineyards. This work aimed at the identification of urinary metabolites of TEB for the biological monitoring of exposure, and to study their kinetics of excretion. Major urinary metabolites of TEB in rats are t-butyl-hydroxy-and-carboxy-tebuconazole (TEB-OH and TEB-COOH). TEB and these metabolites were determined in urine samples of 5 wine growers who collected each void before (24 hours), during and after (48 hours) TEB application. These chemicals were found in 95%, 100% and 100% of the samples with levels of <1.5-13.4 μg/L for TEB, 5.2-749 μg/L for TEB-OH e 2.8-234 Mg/L for TEB-COOH. TEB-OH is the major metabolite of TEB, its concentration increases at the end of exposure and peaks after 16-24 hours. TEB-COOH has similar pattern. TEB-OH and TEB-COO H are promising candidates f or biological monitoring of TEB exposure; preliminary results suggest the day after the application as the best sampling time.
| Original language | Italian |
|---|---|
| Pages (from-to) | 423-424 |
| Number of pages | 2 |
| Journal | Giornale Italiano di Medicina del Lavoro ed Ergonomia |
| Volume | 34 |
| Issue number | 3 |
| Publication status | Published - Jul 2012 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
Cinetica di escrezione del tebuconazolo e dei suoi metaboliti in viticoltori. / Fustinoni, S.; Polledri, E.; Mercadante, R.; Rubino, F.; Colosio, C.; Moretto, A.
In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 34, No. 3, 07.2012, p. 423-424.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cinetica di escrezione del tebuconazolo e dei suoi metaboliti in viticoltori
AU - Fustinoni, S.
AU - Polledri, E.
AU - Mercadante, R.
AU - Rubino, F.
AU - Colosio, C.
AU - Moretto, A.
PY - 2012/7
Y1 - 2012/7
N2 - Tebuconazole (TEB) is a fungicide widely used in vineyards. This work aimed at the identification of urinary metabolites of TEB for the biological monitoring of exposure, and to study their kinetics of excretion. Major urinary metabolites of TEB in rats are t-butyl-hydroxy-and-carboxy-tebuconazole (TEB-OH and TEB-COOH). TEB and these metabolites were determined in urine samples of 5 wine growers who collected each void before (24 hours), during and after (48 hours) TEB application. These chemicals were found in 95%, 100% and 100% of the samples with levels of <1.5-13.4 μg/L for TEB, 5.2-749 μg/L for TEB-OH e 2.8-234 Mg/L for TEB-COOH. TEB-OH is the major metabolite of TEB, its concentration increases at the end of exposure and peaks after 16-24 hours. TEB-COOH has similar pattern. TEB-OH and TEB-COO H are promising candidates f or biological monitoring of TEB exposure; preliminary results suggest the day after the application as the best sampling time.
AB - Tebuconazole (TEB) is a fungicide widely used in vineyards. This work aimed at the identification of urinary metabolites of TEB for the biological monitoring of exposure, and to study their kinetics of excretion. Major urinary metabolites of TEB in rats are t-butyl-hydroxy-and-carboxy-tebuconazole (TEB-OH and TEB-COOH). TEB and these metabolites were determined in urine samples of 5 wine growers who collected each void before (24 hours), during and after (48 hours) TEB application. These chemicals were found in 95%, 100% and 100% of the samples with levels of <1.5-13.4 μg/L for TEB, 5.2-749 μg/L for TEB-OH e 2.8-234 Mg/L for TEB-COOH. TEB-OH is the major metabolite of TEB, its concentration increases at the end of exposure and peaks after 16-24 hours. TEB-COOH has similar pattern. TEB-OH and TEB-COO H are promising candidates f or biological monitoring of TEB exposure; preliminary results suggest the day after the application as the best sampling time.
KW - Biological monitoring
KW - Kinetics of excretion
KW - Tebuconazole
UR - http://www.scopus.com/inward/record.url?scp=84868328957&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868328957&partnerID=8YFLogxK
M3 - Articolo
C2 - 23405679
AN - SCOPUS:84868328957
VL - 34
SP - 423
EP - 424
JO - Giornale Italiano di Medicina del Lavoro ed Ergonomia
JF - Giornale Italiano di Medicina del Lavoro ed Ergonomia
SN - 1592-7830
IS - 3
ER -