Time course of functional connectivity between dorsal premotor and contralateral motor cortex during movement selection

Giacomo Koch, Michele Franca, Miguel Fernandez Del Olmo, Binith Cheeran, Rosemary Milton, Maria Alvarez Sauco, John C. Rothwell

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The left dorsal premotor cortex (PMd) is thought to play a dominant role in the selection of movements made by either hand. We used transcranial magnetic stimulation to study the functional connectivity of the left PMd and right primary motor cortex (M1) during an acoustic choice reaction time (RT) task involving contraction of the thumb and forefinger. The facilitatory and inhibitory pathways that can be demonstrated between left PMd and right M1 at rest were suppressed during most of the reaction period. However, they were activated briefly at the start of the reaction period, depending on whether the cue indicated that the forthcoming movement had to be made with the left or the right hand. The facilitatory pathway was active at 75 ms in those trials in which the subjects were required to move the left hand, whereas the inhibitory pathway was active at 100 ms in trials in which the subjects had to move the right hand. These changes in excitability did not occur in hand muscles not used in the task. There were no significant changes in the excitability of intracortical circuits [short intracortical inhibition (SICI) and intracortical facilitation (ICF)] in the right M1. Interhemispheric interactions between the right PMd and left M1 were mainly inhibitory at rest and showed the same temporal profile of interhemispheric inhibition as for left PMd-right M1, although no evidence was found for facilitatory interactions. The results illustrate the importance of PMd not only in facilitating cued movements but also in suppressing movements that have been prepared but are not used.

Original languageEnglish
Pages (from-to)7452-7459
Number of pages8
JournalJournal of Neuroscience
Volume26
Issue number28
DOIs
Publication statusPublished - 2006

Fingerprint

Motor Cortex
Hand
Transcranial Magnetic Stimulation
Thumb
Acoustics
Reaction Time
Cues
Muscles
Inhibition (Psychology)

Keywords

  • Corticocortical connectivity
  • Movement selection
  • Paired TMS
  • Premotor cortex
  • Time
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Time course of functional connectivity between dorsal premotor and contralateral motor cortex during movement selection. / Koch, Giacomo; Franca, Michele; Del Olmo, Miguel Fernandez; Cheeran, Binith; Milton, Rosemary; Sauco, Maria Alvarez; Rothwell, John C.

In: Journal of Neuroscience, Vol. 26, No. 28, 2006, p. 7452-7459.

Research output: Contribution to journalArticle

Koch, Giacomo ; Franca, Michele ; Del Olmo, Miguel Fernandez ; Cheeran, Binith ; Milton, Rosemary ; Sauco, Maria Alvarez ; Rothwell, John C. / Time course of functional connectivity between dorsal premotor and contralateral motor cortex during movement selection. In: Journal of Neuroscience. 2006 ; Vol. 26, No. 28. pp. 7452-7459.
@article{2df56494afef4f28857c64074314be41,
title = "Time course of functional connectivity between dorsal premotor and contralateral motor cortex during movement selection",
abstract = "The left dorsal premotor cortex (PMd) is thought to play a dominant role in the selection of movements made by either hand. We used transcranial magnetic stimulation to study the functional connectivity of the left PMd and right primary motor cortex (M1) during an acoustic choice reaction time (RT) task involving contraction of the thumb and forefinger. The facilitatory and inhibitory pathways that can be demonstrated between left PMd and right M1 at rest were suppressed during most of the reaction period. However, they were activated briefly at the start of the reaction period, depending on whether the cue indicated that the forthcoming movement had to be made with the left or the right hand. The facilitatory pathway was active at 75 ms in those trials in which the subjects were required to move the left hand, whereas the inhibitory pathway was active at 100 ms in trials in which the subjects had to move the right hand. These changes in excitability did not occur in hand muscles not used in the task. There were no significant changes in the excitability of intracortical circuits [short intracortical inhibition (SICI) and intracortical facilitation (ICF)] in the right M1. Interhemispheric interactions between the right PMd and left M1 were mainly inhibitory at rest and showed the same temporal profile of interhemispheric inhibition as for left PMd-right M1, although no evidence was found for facilitatory interactions. The results illustrate the importance of PMd not only in facilitating cued movements but also in suppressing movements that have been prepared but are not used.",
keywords = "Corticocortical connectivity, Movement selection, Paired TMS, Premotor cortex, Time, Transcranial magnetic stimulation",
author = "Giacomo Koch and Michele Franca and {Del Olmo}, {Miguel Fernandez} and Binith Cheeran and Rosemary Milton and Sauco, {Maria Alvarez} and Rothwell, {John C.}",
year = "2006",
doi = "10.1523/JNEUROSCI.1158-06.2006",
language = "English",
volume = "26",
pages = "7452--7459",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "28",

}

TY - JOUR

T1 - Time course of functional connectivity between dorsal premotor and contralateral motor cortex during movement selection

AU - Koch, Giacomo

AU - Franca, Michele

AU - Del Olmo, Miguel Fernandez

AU - Cheeran, Binith

AU - Milton, Rosemary

AU - Sauco, Maria Alvarez

AU - Rothwell, John C.

PY - 2006

Y1 - 2006

N2 - The left dorsal premotor cortex (PMd) is thought to play a dominant role in the selection of movements made by either hand. We used transcranial magnetic stimulation to study the functional connectivity of the left PMd and right primary motor cortex (M1) during an acoustic choice reaction time (RT) task involving contraction of the thumb and forefinger. The facilitatory and inhibitory pathways that can be demonstrated between left PMd and right M1 at rest were suppressed during most of the reaction period. However, they were activated briefly at the start of the reaction period, depending on whether the cue indicated that the forthcoming movement had to be made with the left or the right hand. The facilitatory pathway was active at 75 ms in those trials in which the subjects were required to move the left hand, whereas the inhibitory pathway was active at 100 ms in trials in which the subjects had to move the right hand. These changes in excitability did not occur in hand muscles not used in the task. There were no significant changes in the excitability of intracortical circuits [short intracortical inhibition (SICI) and intracortical facilitation (ICF)] in the right M1. Interhemispheric interactions between the right PMd and left M1 were mainly inhibitory at rest and showed the same temporal profile of interhemispheric inhibition as for left PMd-right M1, although no evidence was found for facilitatory interactions. The results illustrate the importance of PMd not only in facilitating cued movements but also in suppressing movements that have been prepared but are not used.

AB - The left dorsal premotor cortex (PMd) is thought to play a dominant role in the selection of movements made by either hand. We used transcranial magnetic stimulation to study the functional connectivity of the left PMd and right primary motor cortex (M1) during an acoustic choice reaction time (RT) task involving contraction of the thumb and forefinger. The facilitatory and inhibitory pathways that can be demonstrated between left PMd and right M1 at rest were suppressed during most of the reaction period. However, they were activated briefly at the start of the reaction period, depending on whether the cue indicated that the forthcoming movement had to be made with the left or the right hand. The facilitatory pathway was active at 75 ms in those trials in which the subjects were required to move the left hand, whereas the inhibitory pathway was active at 100 ms in trials in which the subjects had to move the right hand. These changes in excitability did not occur in hand muscles not used in the task. There were no significant changes in the excitability of intracortical circuits [short intracortical inhibition (SICI) and intracortical facilitation (ICF)] in the right M1. Interhemispheric interactions between the right PMd and left M1 were mainly inhibitory at rest and showed the same temporal profile of interhemispheric inhibition as for left PMd-right M1, although no evidence was found for facilitatory interactions. The results illustrate the importance of PMd not only in facilitating cued movements but also in suppressing movements that have been prepared but are not used.

KW - Corticocortical connectivity

KW - Movement selection

KW - Paired TMS

KW - Premotor cortex

KW - Time

KW - Transcranial magnetic stimulation

UR - http://www.scopus.com/inward/record.url?scp=33746091727&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746091727&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.1158-06.2006

DO - 10.1523/JNEUROSCI.1158-06.2006

M3 - Article

C2 - 16837593

AN - SCOPUS:33746091727

VL - 26

SP - 7452

EP - 7459

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 28

ER -