Time course of pressure and flow in ascending aorta during ejection

Stefano Perlini, Pier Luigi Soldà, Massimo Piepoli, Alessandro Calciati, Maurizio Paro, Germano Marchetti, Frank Meno, Giorgio Finardi, Luciano Bernardi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To analyze aortic flow and pressure relationships, 10 closed-chest anaesthetised dogs were instrumented with electromagnetic aortic flow probes and micromanometers in the left ventricle and ascending aorta. Left ventricular ejection time was divided into: time to peak flow (T1) (both pressure and flow rising), peak flow to peak pressure time (T2) (pressure rising, flow decreasing), and peak pressure to dicrotic notch time (T3) (pressure and flow both decreasing). These time intervals were expressed as percent of total ejection time. Load-active interventions rose markedly T2 (from 4.2 ± 5.5 to 19.4 ± 3.5 after phenylephrine (p1-adrenergic stimulation significantly shortens T2. Dynamic pressure-flow relationship is thus continuously changing during ejection. T2 seems to be inversely related to the efficiency of left ventricular ejection dynamics.

Original languageEnglish
Pages (from-to)169-179
Number of pages11
JournalInternational Journal of Cardiology
Volume30
Issue number2
DOIs
Publication statusPublished - 1991

Fingerprint

Aorta
Pressure
Electromagnetic Phenomena
Phenylephrine
Adrenergic Agents
Heart Ventricles
Arterial Pressure
Thorax
Dogs

Keywords

  • Afterload
  • Aortic pressure-flow relationships
  • Ejection dynamics
  • Preload

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Perlini, S., Soldà, P. L., Piepoli, M., Calciati, A., Paro, M., Marchetti, G., ... Bernardi, L. (1991). Time course of pressure and flow in ascending aorta during ejection. International Journal of Cardiology, 30(2), 169-179. https://doi.org/10.1016/0167-5273(91)90092-4

Time course of pressure and flow in ascending aorta during ejection. / Perlini, Stefano; Soldà, Pier Luigi; Piepoli, Massimo; Calciati, Alessandro; Paro, Maurizio; Marchetti, Germano; Meno, Frank; Finardi, Giorgio; Bernardi, Luciano.

In: International Journal of Cardiology, Vol. 30, No. 2, 1991, p. 169-179.

Research output: Contribution to journalArticle

Perlini, S, Soldà, PL, Piepoli, M, Calciati, A, Paro, M, Marchetti, G, Meno, F, Finardi, G & Bernardi, L 1991, 'Time course of pressure and flow in ascending aorta during ejection', International Journal of Cardiology, vol. 30, no. 2, pp. 169-179. https://doi.org/10.1016/0167-5273(91)90092-4
Perlini, Stefano ; Soldà, Pier Luigi ; Piepoli, Massimo ; Calciati, Alessandro ; Paro, Maurizio ; Marchetti, Germano ; Meno, Frank ; Finardi, Giorgio ; Bernardi, Luciano. / Time course of pressure and flow in ascending aorta during ejection. In: International Journal of Cardiology. 1991 ; Vol. 30, No. 2. pp. 169-179.
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