Abstract
To analyze aortic flow and pressure relationships, 10 closed-chest anaesthetised dogs were instrumented with electromagnetic aortic flow probes and micromanometers in the left ventricle and ascending aorta. Left ventricular ejection time was divided into: time to peak flow (T1) (both pressure and flow rising), peak flow to peak pressure time (T2) (pressure rising, flow decreasing), and peak pressure to dicrotic notch time (T3) (pressure and flow both decreasing). These time intervals were expressed as percent of total ejection time. Load-active interventions rose markedly T2 (from 4.2 ± 5.5 to 19.4 ± 3.5 after phenylephrine (p1-adrenergic stimulation significantly shortens T2. Dynamic pressure-flow relationship is thus continuously changing during ejection. T2 seems to be inversely related to the efficiency of left ventricular ejection dynamics.
| Original language | English |
|---|---|
| Pages (from-to) | 169-179 |
| Number of pages | 11 |
| Journal | International Journal of Cardiology |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1991 |
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Keywords
- Afterload
- Aortic pressure-flow relationships
- Ejection dynamics
- Preload
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Time course of pressure and flow in ascending aorta during ejection. / Perlini, Stefano; Soldà, Pier Luigi; Piepoli, Massimo; Calciati, Alessandro; Paro, Maurizio; Marchetti, Germano; Meno, Frank; Finardi, Giorgio; Bernardi, Luciano.
In: International Journal of Cardiology, Vol. 30, No. 2, 1991, p. 169-179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Time course of pressure and flow in ascending aorta during ejection
AU - Perlini, Stefano
AU - Soldà, Pier Luigi
AU - Piepoli, Massimo
AU - Calciati, Alessandro
AU - Paro, Maurizio
AU - Marchetti, Germano
AU - Meno, Frank
AU - Finardi, Giorgio
AU - Bernardi, Luciano
PY - 1991
Y1 - 1991
N2 - To analyze aortic flow and pressure relationships, 10 closed-chest anaesthetised dogs were instrumented with electromagnetic aortic flow probes and micromanometers in the left ventricle and ascending aorta. Left ventricular ejection time was divided into: time to peak flow (T1) (both pressure and flow rising), peak flow to peak pressure time (T2) (pressure rising, flow decreasing), and peak pressure to dicrotic notch time (T3) (pressure and flow both decreasing). These time intervals were expressed as percent of total ejection time. Load-active interventions rose markedly T2 (from 4.2 ± 5.5 to 19.4 ± 3.5 after phenylephrine (p1-adrenergic stimulation significantly shortens T2. Dynamic pressure-flow relationship is thus continuously changing during ejection. T2 seems to be inversely related to the efficiency of left ventricular ejection dynamics.
AB - To analyze aortic flow and pressure relationships, 10 closed-chest anaesthetised dogs were instrumented with electromagnetic aortic flow probes and micromanometers in the left ventricle and ascending aorta. Left ventricular ejection time was divided into: time to peak flow (T1) (both pressure and flow rising), peak flow to peak pressure time (T2) (pressure rising, flow decreasing), and peak pressure to dicrotic notch time (T3) (pressure and flow both decreasing). These time intervals were expressed as percent of total ejection time. Load-active interventions rose markedly T2 (from 4.2 ± 5.5 to 19.4 ± 3.5 after phenylephrine (p1-adrenergic stimulation significantly shortens T2. Dynamic pressure-flow relationship is thus continuously changing during ejection. T2 seems to be inversely related to the efficiency of left ventricular ejection dynamics.
KW - Afterload
KW - Aortic pressure-flow relationships
KW - Ejection dynamics
KW - Preload
UR - http://www.scopus.com/inward/record.url?scp=0026019684&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026019684&partnerID=8YFLogxK
U2 - 10.1016/0167-5273(91)90092-4
DO - 10.1016/0167-5273(91)90092-4
M3 - Article
C2 - 1707037
AN - SCOPUS:0026019684
VL - 30
SP - 169
EP - 179
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 2
ER -