Time course of pressure and flow in ascending aorta during ejection

Stefano Perlini, Pier Luigi Soldà, Massimo Piepoli, Alessandro Calciati, Maurizio Paro, Germano Marchetti, Frank Meno, Giorgio Finardi, Luciano Bernardi

Research output: Contribution to journalArticlepeer-review


To analyze aortic flow and pressure relationships, 10 closed-chest anaesthetised dogs were instrumented with electromagnetic aortic flow probes and micromanometers in the left ventricle and ascending aorta. Left ventricular ejection time was divided into: time to peak flow (T1) (both pressure and flow rising), peak flow to peak pressure time (T2) (pressure rising, flow decreasing), and peak pressure to dicrotic notch time (T3) (pressure and flow both decreasing). These time intervals were expressed as percent of total ejection time. Load-active interventions rose markedly T2 (from 4.2 ± 5.5 to 19.4 ± 3.5 after phenylephrine (p1-adrenergic stimulation significantly shortens T2. Dynamic pressure-flow relationship is thus continuously changing during ejection. T2 seems to be inversely related to the efficiency of left ventricular ejection dynamics.

Original languageEnglish
Pages (from-to)169-179
Number of pages11
JournalInternational Journal of Cardiology
Issue number2
Publication statusPublished - 1991


  • Afterload
  • Aortic pressure-flow relationships
  • Ejection dynamics
  • Preload

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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