Time course of the changes in active and cryoactivatable renin in response to acute stimuli before and after diuretic therapy in man

A. Morganti, C. Sala, L. Turolo, A. Zanchetti

Research output: Contribution to journalArticle

Abstract

In order to elucidate whether inactive renin may represent a precursor of the active enzyme we examined the short-term effects of ambulation and of Captopril administration on active and cryoactivatable renin in patients with essential hypertension before and after 5 days of diuretic therapy. We have found that in the large majority of patients before diuretic the increments in active renin in response to these stimuli were moderate and associated with unchanged levels of cryoactivatable renin; significant decrements in cryoactivatable renin were observed only in a small group of patients in whom the increments in active renin induced by ambulation were unusually rapid and marked. Diuretic therapy caused parallel increments in baseline values of active and of cryoactivatable renin and potentiated the response of the active enzyme to ambulation and to Captopril; however, cryoactivatable renin was still unmodified during both the acute stimuli. Thus, it appears that, normally, the rise in active renin induced by ambulation and Captopril administration is associated, both before and after diuretic therapy, with unchanged levels of the inactive enzyme; however, before diuretic, abrupt increments in the demand for active renin can determine changes in opposite direction of inactive renin as if the latter were a precursor of the former.

Original languageEnglish
Pages (from-to)2403-2413
Number of pages11
JournalClinical and Experimental Hypertension
VolumeA4
Issue number11-12
DOIs
Publication statusPublished - 1982

Fingerprint

Diuretics
Renin
Walking
Captopril
Therapeutics
Enzyme Precursors
Enzymes

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Time course of the changes in active and cryoactivatable renin in response to acute stimuli before and after diuretic therapy in man. / Morganti, A.; Sala, C.; Turolo, L.; Zanchetti, A.

In: Clinical and Experimental Hypertension, Vol. A4, No. 11-12, 1982, p. 2403-2413.

Research output: Contribution to journalArticle

@article{e6145d7afccf4d5ab87fb57ea8342eee,
title = "Time course of the changes in active and cryoactivatable renin in response to acute stimuli before and after diuretic therapy in man",
abstract = "In order to elucidate whether inactive renin may represent a precursor of the active enzyme we examined the short-term effects of ambulation and of Captopril administration on active and cryoactivatable renin in patients with essential hypertension before and after 5 days of diuretic therapy. We have found that in the large majority of patients before diuretic the increments in active renin in response to these stimuli were moderate and associated with unchanged levels of cryoactivatable renin; significant decrements in cryoactivatable renin were observed only in a small group of patients in whom the increments in active renin induced by ambulation were unusually rapid and marked. Diuretic therapy caused parallel increments in baseline values of active and of cryoactivatable renin and potentiated the response of the active enzyme to ambulation and to Captopril; however, cryoactivatable renin was still unmodified during both the acute stimuli. Thus, it appears that, normally, the rise in active renin induced by ambulation and Captopril administration is associated, both before and after diuretic therapy, with unchanged levels of the inactive enzyme; however, before diuretic, abrupt increments in the demand for active renin can determine changes in opposite direction of inactive renin as if the latter were a precursor of the former.",
author = "A. Morganti and C. Sala and L. Turolo and A. Zanchetti",
year = "1982",
doi = "10.3109/10641968209062398",
language = "English",
volume = "A4",
pages = "2403--2413",
journal = "Clinical and Experimental Hypertension",
issn = "1064-1963",
publisher = "Informa Healthcare",
number = "11-12",

}

TY - JOUR

T1 - Time course of the changes in active and cryoactivatable renin in response to acute stimuli before and after diuretic therapy in man

AU - Morganti, A.

AU - Sala, C.

AU - Turolo, L.

AU - Zanchetti, A.

PY - 1982

Y1 - 1982

N2 - In order to elucidate whether inactive renin may represent a precursor of the active enzyme we examined the short-term effects of ambulation and of Captopril administration on active and cryoactivatable renin in patients with essential hypertension before and after 5 days of diuretic therapy. We have found that in the large majority of patients before diuretic the increments in active renin in response to these stimuli were moderate and associated with unchanged levels of cryoactivatable renin; significant decrements in cryoactivatable renin were observed only in a small group of patients in whom the increments in active renin induced by ambulation were unusually rapid and marked. Diuretic therapy caused parallel increments in baseline values of active and of cryoactivatable renin and potentiated the response of the active enzyme to ambulation and to Captopril; however, cryoactivatable renin was still unmodified during both the acute stimuli. Thus, it appears that, normally, the rise in active renin induced by ambulation and Captopril administration is associated, both before and after diuretic therapy, with unchanged levels of the inactive enzyme; however, before diuretic, abrupt increments in the demand for active renin can determine changes in opposite direction of inactive renin as if the latter were a precursor of the former.

AB - In order to elucidate whether inactive renin may represent a precursor of the active enzyme we examined the short-term effects of ambulation and of Captopril administration on active and cryoactivatable renin in patients with essential hypertension before and after 5 days of diuretic therapy. We have found that in the large majority of patients before diuretic the increments in active renin in response to these stimuli were moderate and associated with unchanged levels of cryoactivatable renin; significant decrements in cryoactivatable renin were observed only in a small group of patients in whom the increments in active renin induced by ambulation were unusually rapid and marked. Diuretic therapy caused parallel increments in baseline values of active and of cryoactivatable renin and potentiated the response of the active enzyme to ambulation and to Captopril; however, cryoactivatable renin was still unmodified during both the acute stimuli. Thus, it appears that, normally, the rise in active renin induced by ambulation and Captopril administration is associated, both before and after diuretic therapy, with unchanged levels of the inactive enzyme; however, before diuretic, abrupt increments in the demand for active renin can determine changes in opposite direction of inactive renin as if the latter were a precursor of the former.

UR - http://www.scopus.com/inward/record.url?scp=0020433354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020433354&partnerID=8YFLogxK

U2 - 10.3109/10641968209062398

DO - 10.3109/10641968209062398

M3 - Article

C2 - 6756704

AN - SCOPUS:0020433354

VL - A4

SP - 2403

EP - 2413

JO - Clinical and Experimental Hypertension

JF - Clinical and Experimental Hypertension

SN - 1064-1963

IS - 11-12

ER -