Abstract
250 mg/kg i.p. of the methyl ester of α-methyl-p-tyrosine (α-MpT) produced a rapid increase (by 1 h) in immunoreactive plasma ACTH, whereas the hypothalamic norepinephrine (NE) concentration and plasma corticosterone (B) changed significantly only 6 h after the administration of the inhibitor. These data suggest that the norepinephrinergic inhibitory tonus of CRF-ACTH secretion depends on the availability of a rapidly utilized pool of transmitter, affected in a very short time by α-MpT.
Original language | English |
---|---|
Pages (from-to) | 272-276 |
Number of pages | 5 |
Journal | Neuroendocrinology |
Volume | 18 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1975 |
Keywords
- ACTH
- Corticosterone (Plasma B)
- Norepinephrine (NE)
- α-Methyl-p-tyrosine (α-MpT)
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Cellular and Molecular Neuroscience
- Endocrine and Autonomic Systems
- Neuroscience(all)