Time-course of the effect of α-methyl-p-tyrosine on acth secretion

U. Scapagnini; L. Annunziato; G. Lombardi; Ch Oliver; P. Preziosi

doi:10.1159/000122406

Time-course of the effect of α-methyl-p-tyrosine on acth secretion

U. Scapagnini, L. Annunziato, G. Lombardi, Ch Oliver, P. Preziosi

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Research output: Contribution to journal › Article › peer-review

Abstract

250 mg/kg i.p. of the methyl ester of α-methyl-p-tyrosine (α-MpT) produced a rapid increase (by 1 h) in immunoreactive plasma ACTH, whereas the hypothalamic norepinephrine (NE) concentration and plasma corticosterone (B) changed significantly only 6 h after the administration of the inhibitor. These data suggest that the norepinephrinergic inhibitory tonus of CRF-ACTH secretion depends on the availability of a rapidly utilized pool of transmitter, affected in a very short time by α-MpT.

Original language	English
Pages (from-to)	272-276
Number of pages	5
Journal	Neuroendocrinology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1159/000122406
Publication status	Published - 1975

Keywords

ACTH
Corticosterone (Plasma B)
Norepinephrine (NE)
α-Methyl-p-tyrosine (α-MpT)

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Cellular and Molecular Neuroscience
Endocrine and Autonomic Systems
Neuroscience(all)

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10.1159/000122406

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title = "Time-course of the effect of α-methyl-p-tyrosine on acth secretion",

abstract = "250 mg/kg i.p. of the methyl ester of α-methyl-p-tyrosine (α-MpT) produced a rapid increase (by 1 h) in immunoreactive plasma ACTH, whereas the hypothalamic norepinephrine (NE) concentration and plasma corticosterone (B) changed significantly only 6 h after the administration of the inhibitor. These data suggest that the norepinephrinergic inhibitory tonus of CRF-ACTH secretion depends on the availability of a rapidly utilized pool of transmitter, affected in a very short time by α-MpT.",

keywords = "ACTH, Corticosterone (Plasma B), Norepinephrine (NE), α-Methyl-p-tyrosine (α-MpT)",

author = "U. Scapagnini and L. Annunziato and G. Lombardi and Ch Oliver and P. Preziosi",

year = "1975",

doi = "10.1159/000122406",

language = "English",

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pages = "272--276",

journal = "Neuroendocrinology",

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T1 - Time-course of the effect of α-methyl-p-tyrosine on acth secretion

AU - Scapagnini, U.

AU - Annunziato, L.

AU - Lombardi, G.

AU - Oliver, Ch

AU - Preziosi, P.

PY - 1975

Y1 - 1975

N2 - 250 mg/kg i.p. of the methyl ester of α-methyl-p-tyrosine (α-MpT) produced a rapid increase (by 1 h) in immunoreactive plasma ACTH, whereas the hypothalamic norepinephrine (NE) concentration and plasma corticosterone (B) changed significantly only 6 h after the administration of the inhibitor. These data suggest that the norepinephrinergic inhibitory tonus of CRF-ACTH secretion depends on the availability of a rapidly utilized pool of transmitter, affected in a very short time by α-MpT.

AB - 250 mg/kg i.p. of the methyl ester of α-methyl-p-tyrosine (α-MpT) produced a rapid increase (by 1 h) in immunoreactive plasma ACTH, whereas the hypothalamic norepinephrine (NE) concentration and plasma corticosterone (B) changed significantly only 6 h after the administration of the inhibitor. These data suggest that the norepinephrinergic inhibitory tonus of CRF-ACTH secretion depends on the availability of a rapidly utilized pool of transmitter, affected in a very short time by α-MpT.

KW - ACTH

KW - Corticosterone (Plasma B)

KW - Norepinephrine (NE)

KW - α-Methyl-p-tyrosine (α-MpT)

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ER -

Time-course of the effect of α-methyl-p-tyrosine on acth secretion

Abstract

Keywords

ASJC Scopus subject areas

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