Time-course of the effect of α-methyl-p-tyrosine on acth secretion

U. Scapagnini, L. Annunziato, G. Lombardi, Ch Oliver, P. Preziosi

Research output: Contribution to journalArticlepeer-review


250 mg/kg i.p. of the methyl ester of α-methyl-p-tyrosine (α-MpT) produced a rapid increase (by 1 h) in immunoreactive plasma ACTH, whereas the hypothalamic norepinephrine (NE) concentration and plasma corticosterone (B) changed significantly only 6 h after the administration of the inhibitor. These data suggest that the norepinephrinergic inhibitory tonus of CRF-ACTH secretion depends on the availability of a rapidly utilized pool of transmitter, affected in a very short time by α-MpT.

Original languageEnglish
Pages (from-to)272-276
Number of pages5
Issue number3
Publication statusPublished - 1975


  • ACTH
  • Corticosterone (Plasma B)
  • Norepinephrine (NE)
  • α-Methyl-p-tyrosine (α-MpT)

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)


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