Abstract
The cytotoxicity of hexamethylmelamine (HMM) and its metabolites pentamethylmelamine (PMM), N,2,2,4,6-tetramethylmelamine (TMM) and hydroxymethylpentamethylmelamine (HMPMM) and of the alkylating agent triethylene-melamine (TEM) were studied on a cell line derived from a human ovarian cancer, by measuring [3H]TdR uptake. After 24 h of incubation all the tested compounds inhibited [3H]TdR uptake, but only at a concentration of 100μg/ml. However, after 120 h incubation concentrations of 0.1-10 μg/ml resulted in highly significant cytotoxicity. HMPMM and TEM were the most active and their effect was not reversed 72 h after their removal. In our in vitro system no metabolism of HMM was observed.
| Original language | English |
|---|---|
| Pages (from-to) | 630-635 |
| Number of pages | 6 |
| Journal | British Journal of Cancer |
| Volume | 41 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1980 |
ASJC Scopus subject areas
- Cancer Research
- Oncology
Fingerprint Dive into the research topics of 'Time dependence of the in vitro cytotoxicity of hexamethylmelamine and its metabolites'. Together they form a unique fingerprint.
Cite this
D'incalci, M., Erba, E., Balconi, G., Morasca, L., & Garattini, S. (1980). Time dependence of the in vitro cytotoxicity of hexamethylmelamine and its metabolites. British Journal of Cancer, 41(4), 630-635. https://doi.org/10.1038/bjc.1980.106