Time-dependent changes in adrenal cortex ultrastructure and corticosterone levels after noise exposure in male rats

Marco Gesi, F. Fornai, P. Lenzi, G. Natale, P. Soldani, A. Paparelli

Research output: Contribution to journalArticlepeer-review

Abstract

In response to a stressful stimulus, there is a marked activation of the hypothalamic-pituitary-adrenal axis leading to a release of adrenocorticotropic hormone. This, in turn, acts on the zona fasciculata of the adrenal cortex to increase corticosterone plasma levels. Given the frequency of chronic intermittent noise exposure in man, we selected loud noise to evaluate concomitant changes in the ultrastructure of the adrenal cortex and corticosterone release. Following chronic (21 days, 6h per day) loud white noise exposure (100 dBA, 0-26 KHz), we found the zona fasciculata to be most sensitive to time-dependent ultrastructural changes. These consisted of modifications in cell compartments involved in hormone synthesis and release. On the other hand, we found a progressive increase in corticosterone plasma levels which reached a plateau 9 days after noise exposure. The significance of these changes, in relation to phenomena like sensitization to repetitive stress, are discussed. Furthermore, the present data suggest that chronic loud noise exposure might potentially lead to endocrine dysfunctions.

Original languageEnglish
Pages (from-to)129-135
Number of pages7
JournalEuropean Journal of Morphology
Volume39
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • Adrenal cortex
  • Corticosterone
  • Electron microscopy
  • Male rat
  • Noise stress

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Fingerprint Dive into the research topics of 'Time-dependent changes in adrenal cortex ultrastructure and corticosterone levels after noise exposure in male rats'. Together they form a unique fingerprint.

Cite this