Adriamycin and daunomycin exert a cytotoxic effect on primary cultures of mammary carcinoma in (C3H × O20) F1 mice. This effect increases with the time of contact with cells and with the time elapsed between the end of the treatment and the evaluation of the effect. Daunomycin appears to be more cytotoxic than adriamycin while both antibiotics are more active on the cancer cells than on cultures of lactating mammary glands. Some known metabolites of daunomycin (the aglicones of daunorubicinol, daunomycin and 7-deoxydaunorubicinol) and the aglicone of adriamycin appear to be inactive on the mammary carcinoma in vitro. Daunorubicinol shows instead an activity which is 10-40 times lower than daunomycin.
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