Time dependent cytotoxicity of adriamycin and daunomycin in primary cultures of normal and neoplastic mammary glands

L. Morasca, E. G. Fogar-Ottaviano, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

Adriamycin and daunomycin exert a cytotoxic effect on primary cultures of mammary carcinoma in (C3H × O20) F1 mice. This effect increases with the time of contact with cells and with the time elapsed between the end of the treatment and the evaluation of the effect. Daunomycin appears to be more cytotoxic than adriamycin while both antibiotics are more active on the cancer cells than on cultures of lactating mammary glands. Some known metabolites of daunomycin (the aglicones of daunorubicinol, daunomycin and 7-deoxydaunorubicinol) and the aglicone of adriamycin appear to be inactive on the mammary carcinoma in vitro. Daunorubicinol shows instead an activity which is 10-40 times lower than daunomycin.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalEuropean Journal of Cancer (1965)
Volume12
Issue number2
DOIs
Publication statusPublished - 1976

ASJC Scopus subject areas

  • Oncology

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