Time-dependent increase of glomerular filtration rate after oral protein load: Evidence for diurnal variations in renal response

C. Buzio, P. Quaretti, L. Arisi, A. Negro, R. Barani, M. G. Alquati

Research output: Contribution to journalArticlepeer-review

Abstract

Seven healthy male volunteers were studied to test the effect of timing of an oral protein load on renal function. Creatinine clearance (Ccr) was measured during the 4-h period after administration of 72 g of protein in the form of cooked red meat at 1200 hours (lunch protein load, PL) and at 2000 hours (supper PL) the next evening. A low-protein meal in the form of vegetables was given as a control load at 2000 hours on the first day (supper control load, CL) and at 1200 hours on the second day (lunch CL). The 12-h night-time Ccr at fasting was used as the baseline reference value. After the lunch PL, Ccr (mean 127±6.8 ml/min) was 45% (p

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume48
Issue number1
DOIs
Publication statusPublished - 1988

Keywords

  • Circadian rhythm
  • Creatinine clearance
  • Glomerular hyperfiltration
  • Protein intake
  • Renal functional reserve

ASJC Scopus subject areas

  • Clinical Biochemistry

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