TY - JOUR
T1 - Time-dependent relevance of steroid receptors in breast cancer
AU - Coradini, Danila
AU - Daidone, Maria Grazia
AU - Boracchi, Patrizia
AU - Biganzoli, Elia
AU - Oriana, Saro
AU - Bresciani, Gianluigi
AU - Pellizzaro, Cinzia
AU - Tomasic, Gorana
AU - Di Fronzo, Giovanni
AU - Marubini, Ettore
PY - 2000/7
Y1 - 2000/7
N2 - Purpose: To analyze the time-dependent prognostic role of the investigated variables, considered, when appropriate, on a continuous scale, for the purpose of evaluating and describing the interrelationships between clinically relevant patient and tumor characteristics (age, size and histology, and estrogen receptor [ER] and progesterone receptor content) and the risk of new disease manifestation. Patients and Methods: We applied a flexible statistical model to a case series of 1,793 patients with axillary lymph node-negative breast cancer with a minimal potential follow-up of 10 years. To avoid a potential confounding effect of adjuvant treatment, only patients given local-regional therapy until relapse were considered. Results: ER content and tumor size (adjusted for all the other covariates) showed a time- dependent relationship with the risk of new disease manifestations. In particular, ER content failed to show a prognostic effect within the first years of follow-up; thereafter, a positive association with risk of relapse was observed. For tumor size, within the first years of follow-up, the risk of relapse was directly related to size for only tumors up to 2.5 cm in diameter; thereafter, the impact on prognosis progressively decreased. Conclusion: The availability of a long- follow-up on a large breast cancer series, as well as the use of innovative statistical approaches, allowed us to explore the functional relation between sterid receptors and clinical outcome and to generate a hypothesis on the involvement of ER in favoring long-term metastasis development. (C) 2000 by American Society of Clinical Oncology.
AB - Purpose: To analyze the time-dependent prognostic role of the investigated variables, considered, when appropriate, on a continuous scale, for the purpose of evaluating and describing the interrelationships between clinically relevant patient and tumor characteristics (age, size and histology, and estrogen receptor [ER] and progesterone receptor content) and the risk of new disease manifestation. Patients and Methods: We applied a flexible statistical model to a case series of 1,793 patients with axillary lymph node-negative breast cancer with a minimal potential follow-up of 10 years. To avoid a potential confounding effect of adjuvant treatment, only patients given local-regional therapy until relapse were considered. Results: ER content and tumor size (adjusted for all the other covariates) showed a time- dependent relationship with the risk of new disease manifestations. In particular, ER content failed to show a prognostic effect within the first years of follow-up; thereafter, a positive association with risk of relapse was observed. For tumor size, within the first years of follow-up, the risk of relapse was directly related to size for only tumors up to 2.5 cm in diameter; thereafter, the impact on prognosis progressively decreased. Conclusion: The availability of a long- follow-up on a large breast cancer series, as well as the use of innovative statistical approaches, allowed us to explore the functional relation between sterid receptors and clinical outcome and to generate a hypothesis on the involvement of ER in favoring long-term metastasis development. (C) 2000 by American Society of Clinical Oncology.
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M3 - Article
C2 - 10894869
AN - SCOPUS:18344407771
VL - 18
SP - 2702
EP - 2709
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
SN - 0732-183X
IS - 14
ER -