Time from nephrectomy as a prognostic factor in metastatic renal cell carcinoma patients receiving targeted therapies: Overall results from a large cohort of patients

Giuseppe Procopio, Isabella Testa, Elena Verzoni, Roberto Iacovelli, Paolo Grassi, Giulia Galli, Filippo De Braud, Diana Saravia, Roberto Salvioni

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate whether time from nephrectomy (Nx) to the diagnosis of metastatic disease may be an independent prognostic factor in metastatic renal cell carcinoma (mRCC) patients treated with targeted therapies (TTs). Subjects and Methods: All patients who underwent Nx and at least 1 TT were considered. The patients were divided into two groups based on time from Nx [>1 year (Nx >1) and 1 year in 47%, 1 group, 24.3 months (95% CI 17.7-31) for the Nx 1 vs. cNx: HR = 0.43, 95% CI 0.31-0.61, p <0.001). Conclusion: We report that time from Nx is an independent prognostic factor for OS in patients affected by mRCC treated with TTs.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalOncology
Volume88
Issue number3
DOIs
Publication statusPublished - Mar 6 2015

Keywords

  • Cytoreductive nephrectomy
  • Nephrectomy
  • Prognostic factors
  • Renal cell carcinoma
  • Targeted therapies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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