@article{36612f40ecbc4c178f3e0bb542f3a1d6,
title = "{\textquoteleft}Time is prognosis{\textquoteright} in heart failure: time-to-treatment initiation as a modifiable risk factor",
abstract = "In heart failure (HF), acute decompensation can occur quickly and unexpectedly because of worsening of chronic HF or to new-onset HF diagnosed for the first time ({\textquoteleft}de novo{\textquoteright}). Patients presenting with acute HF (AHF) have a poor prognosis comparable with those with acute myocardial infarction, and any delay of treatment initiation is associated with worse outcomes. Recent HF guidelines and recommendations have highlighted the importance of a timely diagnosis and immediate treatment for patients presenting with AHF to decrease disease progression and improve prognosis. However, based on the available data, there is still uncertainty regarding the optimal {\textquoteleft}time-to-treatment{\textquoteright} effect in AHF. Furthermore, the immediate post-worsening HF period plays an important role in clinical outcomes in HF patients after hospitalization and is known as the {\textquoteleft}vulnerable phase{\textquoteright} characterized by high risk of readmission and early death. Early and intensive treatment for HF patients in the {\textquoteleft}vulnerable phase{\textquoteright} might be associated with lower rates of early readmission and mortality. Additionally, in the chronic stable HF outpatient, treatments are often delayed or not initiated when symptoms are stable, ignoring the risk for adverse outcomes such as sudden death. Consequently, there is a dire need to better identify HF patients during hospitalization and after discharge and treating them adequately to improve their prognosis. HF is an urgent clinical scenario along all its stages and disease conditions. Therefore, time plays a significant role throughout the entire patient's journey. Therapy should be optimized as soon as possible, because this is beneficial regardless of severity or duration of HF. Time lavished before treatment initiation is recognized as important modifiable risk factor in HF.",
keywords = "Heart failure, Prognosis, Treatment",
author = "Amr Abdin and Anker, {Stefan D.} and Javed Butler and Coats, {Andrew J.Stewart} and Ingrid Kindermann and Mitja Lainscak and Lund, {Lars H.} and Marco Metra and Wilfried Mullens and Giuseppe Rosano and Jonathan Slawik and Jan Wintrich and Michael B{\"o}hm",
note = "Funding Information: I.K. and M.B. are supported by the German Research Foundation (Deutsche Forschungsgemeinschaft; TTR 219, Project No. 322900939). M.L. was funded by the Slovenian Research Agency (Javna Agencija za Raziskovalno Dejavnost RS; Research Grant Nos. J3‐9292 and J3‐9284). Funding Information: A.A. received speaker's honoraria from Novartis and travel grants from Biotronik and Novartis. S.D.A. received honoraria for lectures and scientific advice from Vifor, Bayer, Boehringer Ingelheim, Novartis, Servier, Abbott, Actimed, Cardiac Dimensions, and Impulse Dynamics. J.B. received honoraria for lectures and scientific advice from Abbott, Adrenomed, Amgen, Applied Therapeutics, Array, AstraZeneca, Bayer, Boehringer Ingelheim, CVRx, G3 Pharma, Novartis, BI‐Lilly, and Janssen. A.J.S.C. received grants and personal fees from Vifor International and personal fees from AstraZeneca, Bayer, Boehringer Ingelheim, Menarini, Novartis, Nutricia, Servier, Vifor, Abbott, Actimed, Arena, Cardiac Dimensions, Corvia, CVRx, Enopace, ESN Cleer, Faraday, Gore, Impulse Dynamics, and Respicardia. I.K. reports personal fees from Akcea Therapeutics Germany GmbH, AstraZeneca, Bayer Vital GmbH, Boehringer Ingelheim, Bristol Myers Squibb Company, Hexal AG, Novartis, Pfizer Pharma GmbH, Servier Deutschland GmbH, Vifor, and Daiichi Sankyo Deutschland GmbH. M.L. reports personal fees from AstraZeneca, Bayer, Boehringer Ingelheim, Vifor Pharma, and Novartis. L.H.L. received grants and personal fees from Relypsa, Boehringer Ingelheim, and Novartis, grants from Boston Scientific, and personal fees from Merck, Vifor Fresenius, AstraZeneca, Bayer, Pharmacosmos, Abbott, Medscape, Myokardia, Sanofi, Lexicon, and Mundipharma. M.M. received personal fees and non‐financial support from Amgen, Abbott Vascular, and Bayer and personal fees from Servier, AstraZeneca, Edwards Therapeutics, Vifor Pharma, Actelion, LivaNova, and Windtree Therapeutics. W.M. received research grants from Novartis, Vifor, Medtronic, Biotronik, Abbott, and Boston Scientific. M.B. reports personal fees from Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Cytokinetics, Medtronic, Novartis, Servier, and Vifor. Publisher Copyright: {\textcopyright} 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.",
year = "2021",
month = dec,
day = "8",
doi = "10.1002/ehf2.13646",
language = "English",
pages = "4444--4453",
journal = "ESC heart failure",
issn = "2055-5822",
publisher = "Wiley Blackwell",
}