Time pattern of gastric acidity in Barrett's esophagus

Vincenzo Savarino, Giuseppe Sandro Mela, Patrizia Zentilin, Maria Raffaella Mele, Carlo Mansi, Anna Carla Remagnino, Sergio Vigneri, Alberto Malesci, Monica Belicchi, Gabriella Lapertosa, Guido Celle

Research output: Contribution to journalArticlepeer-review


Increased gastroesophageal acid reflux is frequently found in patients with Barrett's esophagus, and it has been hypothesized that gastric acid hypersecretion could be an important factor aggravating the exposure of esophageal mucosa to acid and then contributing to the development of this disorder. The aim of the present study was to assess whether the circadian pattern of gastric acidity differs between refluxer patients with and without Barrett's esophagus and normal subjects. Continuous 24-hr gastric pH monitoring was performed in 119 healthy volunteers, 20 patients with Barrett's esophagus, 37 patients with moderate and 10 patients with severe reflux esophagitis without Barrett's esophagus. In all these diseases the final diagnosis was ascertained by means of endoscopy plus biopsy. There was no difference in the 24-hr and daytime patterns of gastric pH between healthy subjects and patients with Barrett's esophagus, while nocturnal acidity was significantly lower (P <0.05) in the latter population. Gastric acidity, in contrast, was higher (P <0.05) in controls than in patients with both moderate and severe reflux esophagitis without Barrett's esophagus during the whole 24-hr period. There was no difference between refluxer patients with and without Barrett's esophagus in any of the three time intervals we analyzed. Because normal subjects had lower gastric pH than patients with Barrett's esophagus during the night and than patients with reflux esophagitis during the whole 24-hr period, gastric hyperacidity is not a relevant factor in the development of both metaplastic columnar epithelium and inflammatory changes in the distal esophagus, and other pathophysiological mechanisms are involved in these histological alterations.

Original languageEnglish
Pages (from-to)1379-1383
Number of pages5
JournalDigestive Diseases and Sciences
Issue number7
Publication statusPublished - 1996


  • Barrett's esophagus
  • gastric acidity
  • pH monitoring
  • reflux esophagitis

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Time pattern of gastric acidity in Barrett's esophagus'. Together they form a unique fingerprint.

Cite this