Time-related decrease in sensitivity to ergonovine in patients with variant angina

Mario Previtali, Claudio Panciroli, Roberto De Ponti, Marcello Chimienti, Carlo Montemartini, Jorge A. Salerno

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Abstract

Eighteen patients with variant angina, a positive ergonovine test, and a favorable response to calcium antagonists were studied by serial ergonovine tests and Holter monitoring to assess the long-term changes in response to ergonovine and the relationship with the spontaneous activity of the disease. The number of patients with a positive test decreased from 18 of 18 in the acute phase to 12 of 18 (66%) at 3 months, 10 of 17 (59%) at 6 months, and five of 17 (29%) at 12 months. The mean dose level of ergonovine associated with a positive response and the percentage of positive tests with ST segment depression increased progresively during follow-up. The results of the ergonovine test were well correlated with the spontaneous activity of the disease in 94%, 83%, 76%, and 71% of the patients at initial observation and at 3, 6 and 12 months, respectively. Thus in patients with variant angina and a favorable response to calcium antagonists, a time-related decrease in sensitivity to ergonovine develops during follow-up. In most patients the response to ergonovine is well correlated with the spontaneous activity of the disease; thus the ergonovine test may be a useful tool in the assessment of the natural evolution of vasospastic angina.

Original languageEnglish
Pages (from-to)92-99
Number of pages8
JournalAmerican Heart Journal
Volume117
Issue number1
DOIs
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Previtali, M., Panciroli, C., Ponti, R. D., Chimienti, M., Montemartini, C., & Salerno, J. A. (1989). Time-related decrease in sensitivity to ergonovine in patients with variant angina. American Heart Journal, 117(1), 92-99. https://doi.org/10.1016/0002-8703(89)90661-3