Time-related effects of gonadotropin-releasing hormone analog treatment in experimentally induced endometriosis in the rat

V. L. Zanagnolo, R. Beck, W. D. Schlaff, M. D. Damewood, D. Bobbie, J. A. Rock

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Abstract

The purpose of our study was to characterize the time-dependent effect of gonadotropin-releasing hormone analog (GnRH-a) therapy on endometriosis explant using the rat model. Endometriosis was induced in 60 mature female rats. One group of treated animals as well as controls were killed at 2, 4, 6, and 8 weeks of treatment at which time the explant was evaluated. Explant volume was significantly reduced in all treatment groups, an effect that was more significant in animals treated for ≥4 weeks compared with those treated for only 2 weeks. We conclude that GnRH-a treatment caused gradual regression of endometrial explant that was effectively complete by 4 weeks of treatment. We further conclude that this experimental model may be useful in the evaluation of other modes of endometriosis therapy.

Original languageEnglish
Pages (from-to)411-415
Number of pages5
JournalFertility and Sterility
Volume55
Issue number2
Publication statusPublished - 1991

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Endometriosis
Gonadotropin-Releasing Hormone
Theoretical Models
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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Time-related effects of gonadotropin-releasing hormone analog treatment in experimentally induced endometriosis in the rat. / Zanagnolo, V. L.; Beck, R.; Schlaff, W. D.; Damewood, M. D.; Bobbie, D.; Rock, J. A.

In: Fertility and Sterility, Vol. 55, No. 2, 1991, p. 411-415.

Research output: Contribution to journalArticle

Zanagnolo, V. L. ; Beck, R. ; Schlaff, W. D. ; Damewood, M. D. ; Bobbie, D. ; Rock, J. A. / Time-related effects of gonadotropin-releasing hormone analog treatment in experimentally induced endometriosis in the rat. In: Fertility and Sterility. 1991 ; Vol. 55, No. 2. pp. 411-415.
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