Time since menopause influences the acute and chronic effect of estrogens on endothelial function

Cristiana Vitale, Giuseppe Mercuro, Elena Cerquetani, Giuseppe Marazzi, Roberto Patrizi, Francesco Pelliccia, Maurizio Volterrani, Massimo Fini, Peter Collins, Giuseppe M C Rosano

Research output: Contribution to journalArticle

Abstract

OBJECTIVE - We evaluated whether time since menopause influences the acute and chronic effect of Estradiol (E) on vascular endothelial function. METHODS AND RESULTS - We studied flow-mediated dilatation (FMD) in 134 postmenopausal women (PMW) before and after acute and chronic E administration. At baseline FMD was inversely associated to time from menopause (r=-0.67, P

Original languageEnglish
Pages (from-to)348-352
Number of pages5
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume28
Issue number2
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Cardiovascular disease prevention
  • Endothelial function
  • Endothelium
  • Estrogen
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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