Time to smoke first morning cigarette and lung cancer in a case-control study

Fangyi Gu, Sholom Wacholder, Stephanie Kovalchik, Orestis A. Panagiotou, Carolyn Reyes-Guzman, Neal D. Freedman, Sara De Matteis, Dario Consonni, Pier Alberto Bertazzi, Andrew W. Bergen, Maria Teresa Landi, Neil E. Caporaso

Research output: Contribution to journalArticle

Abstract

Background Targeting smokers at higher lung cancer risk can improve efficiency and reduce false-positive detection in lung cancer screening. We evaluated whether time to first cigarette after waking (TTFC), a single-item measure of nicotine dependency, could improve stratification of lung cancer risk beyond standard smoking metrics (intensity, duration, and pack-years). Methods In 3249 ever-smokers (n = 1812 case subjects; n = 1437 control subjects) from a population-based case-control study in Italy, we examined the association between TTFC and lung cancer using logistic regression and estimated lung cancer incidence by levels of TTFC, and intensity, duration, and pack-years using absolute risk regression. Significance tests were two-sided. Results Compared with smokers with TTFC greater than 60 minutes, the lung cancer odds ratios for TTFC of 31 to 60 minutes, 6 to 30 minutes, and 5 or fewer minutes (by increasing dependency) were 2.57 (95% confidence interval [CI] = 2.03 to 3.26), 2.27 (95% CI = 1.79 to 2.88), and 3.50 (95% CI = 2.64 to 4.64), respectively (P trend interaction

Original languageEnglish
JournalJournal of the National Cancer Institute
Volume106
Issue number6
DOIs
Publication statusPublished - Jun 11 2014

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Smoke
Tobacco Products
Case-Control Studies
Lung Neoplasms
Confidence Intervals
Nicotine
Early Detection of Cancer
Italy
Logistic Models
Smoking
Odds Ratio
Incidence
Population
Dependency (Psychology)

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Gu, F., Wacholder, S., Kovalchik, S., Panagiotou, O. A., Reyes-Guzman, C., Freedman, N. D., ... Caporaso, N. E. (2014). Time to smoke first morning cigarette and lung cancer in a case-control study. Journal of the National Cancer Institute, 106(6). https://doi.org/10.1093/jnci/dju118

Time to smoke first morning cigarette and lung cancer in a case-control study. / Gu, Fangyi; Wacholder, Sholom; Kovalchik, Stephanie; Panagiotou, Orestis A.; Reyes-Guzman, Carolyn; Freedman, Neal D.; De Matteis, Sara; Consonni, Dario; Bertazzi, Pier Alberto; Bergen, Andrew W.; Landi, Maria Teresa; Caporaso, Neil E.

In: Journal of the National Cancer Institute, Vol. 106, No. 6, 11.06.2014.

Research output: Contribution to journalArticle

Gu, F, Wacholder, S, Kovalchik, S, Panagiotou, OA, Reyes-Guzman, C, Freedman, ND, De Matteis, S, Consonni, D, Bertazzi, PA, Bergen, AW, Landi, MT & Caporaso, NE 2014, 'Time to smoke first morning cigarette and lung cancer in a case-control study', Journal of the National Cancer Institute, vol. 106, no. 6. https://doi.org/10.1093/jnci/dju118
Gu F, Wacholder S, Kovalchik S, Panagiotou OA, Reyes-Guzman C, Freedman ND et al. Time to smoke first morning cigarette and lung cancer in a case-control study. Journal of the National Cancer Institute. 2014 Jun 11;106(6). https://doi.org/10.1093/jnci/dju118
Gu, Fangyi ; Wacholder, Sholom ; Kovalchik, Stephanie ; Panagiotou, Orestis A. ; Reyes-Guzman, Carolyn ; Freedman, Neal D. ; De Matteis, Sara ; Consonni, Dario ; Bertazzi, Pier Alberto ; Bergen, Andrew W. ; Landi, Maria Teresa ; Caporaso, Neil E. / Time to smoke first morning cigarette and lung cancer in a case-control study. In: Journal of the National Cancer Institute. 2014 ; Vol. 106, No. 6.
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