Andamento nel tempo dell'incidenza dei tumori maligni nei residenti nella Provincia di Trieste sotto i 25 anni d'età, 1972-2003

Translated title of the contribution: Time trend in cancer incidence among 0-24 year-old residents of the Province of Trieste, Italy, 1972-2003

Davide Brunetti, Paolo Tamaro, Mario Tiribelli, Renato Fanin, Giorgio Stanta, Giulio Andrea Zanazzo, Paolo Peruzzo, Francesca Carobolante, Valentina Kiren, Diego Serraino

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: to report and analyse time trends in cancer incidence among children (0-14 years of age), adolescents (15-19 years) and young adults (20-24 years) living in the Italian province of Trieste (2003population, 242,000), between 1972and2003. Design: population-based study of descriptive epidemiology. Setting and participants: the new cases of cancer diagnosed to the residents of the province of Trieste below 25 years of age were extracted from the database of the Trieste Cancer Registry (period 1972-1994) and from the database of the Friuli-Venezia Giulia Cancer Registry (period 1995-2003), according to the International Classification of Childhood Cancer (3rd edition). Main outcome measures: age-specific and age-standardized (Italian 1981 census population as standard) incidence rates, by diagnostic group, sex and period of diagnosis. Time trend in incidence was analysed by using a Poisson regression model adjusted for calendar year, sex and 5 year age-group, and was expressed as annual percent change (ARC) in rates. Results: in the period 1972-2003, the new cases of cancer were 168 in the age-group 0-14years, 79 in the age-group 15-19yean and 111 in the age-group 20-24 years, while the person-years at risk were respectively: 1,050,027;431,673;496,450. The ARC in the incidence of all cancers combined was 2.3% (IC 95% 0.6%-3.9%) in children, 4.4% (IC95% 1.8%-7.1%) in adolescents and 5.1% (IC 95% 2.8%-75%) in young adults. Hodgkin lymphomas (ARC =12.7%; IC95% 2.6%-23.7%; 7 cases) in the age-group 0-14 years, skin melanomas and carcinomas (APC =8.2%; IC95% 4.5% - 12.0%; 49 cases) and central nervous system tumours (APC = 6.4%; IC95% 1.5%-11.5%; 25 cases) in the age-group 15-24 years were the malignancies characterised by the highest increase in incidence. Conclusion: the increase in incidence rates observed in this study can be only partly explained by the small number of ascertained cases, by an improvement in diagnostic techniques and by more efficient registration. However, few environmental and hereditary factors are consistently associated with cancers affecting young people. Therefore, it is imperative to continue to carry out descriptive and analytical studies with primary prevention as the ultimate aim.

Original languageItalian
Pages (from-to)161-168
Number of pages8
JournalEpidemiologia e prevenzione
Volume33
Issue number4-5
Publication statusPublished - Jul 2009

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Italy
Incidence
Age Groups
Neoplasms
Registries
Young Adult
Databases
Central Nervous System Neoplasms
Censuses
Primary Prevention
Hodgkin Disease
Population
Melanoma
Epidemiology
Outcome Assessment (Health Care)
Carcinoma
Skin

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Andamento nel tempo dell'incidenza dei tumori maligni nei residenti nella Provincia di Trieste sotto i 25 anni d'età, 1972-2003. / Brunetti, Davide; Tamaro, Paolo; Tiribelli, Mario; Fanin, Renato; Stanta, Giorgio; Zanazzo, Giulio Andrea; Peruzzo, Paolo; Carobolante, Francesca; Kiren, Valentina; Serraino, Diego.

In: Epidemiologia e prevenzione, Vol. 33, No. 4-5, 07.2009, p. 161-168.

Research output: Contribution to journalArticle

Brunetti, D, Tamaro, P, Tiribelli, M, Fanin, R, Stanta, G, Zanazzo, GA, Peruzzo, P, Carobolante, F, Kiren, V & Serraino, D 2009, 'Andamento nel tempo dell'incidenza dei tumori maligni nei residenti nella Provincia di Trieste sotto i 25 anni d'età, 1972-2003', Epidemiologia e prevenzione, vol. 33, no. 4-5, pp. 161-168.
Brunetti, Davide ; Tamaro, Paolo ; Tiribelli, Mario ; Fanin, Renato ; Stanta, Giorgio ; Zanazzo, Giulio Andrea ; Peruzzo, Paolo ; Carobolante, Francesca ; Kiren, Valentina ; Serraino, Diego. / Andamento nel tempo dell'incidenza dei tumori maligni nei residenti nella Provincia di Trieste sotto i 25 anni d'età, 1972-2003. In: Epidemiologia e prevenzione. 2009 ; Vol. 33, No. 4-5. pp. 161-168.
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abstract = "Objective: to report and analyse time trends in cancer incidence among children (0-14 years of age), adolescents (15-19 years) and young adults (20-24 years) living in the Italian province of Trieste (2003population, 242,000), between 1972and2003. Design: population-based study of descriptive epidemiology. Setting and participants: the new cases of cancer diagnosed to the residents of the province of Trieste below 25 years of age were extracted from the database of the Trieste Cancer Registry (period 1972-1994) and from the database of the Friuli-Venezia Giulia Cancer Registry (period 1995-2003), according to the International Classification of Childhood Cancer (3rd edition). Main outcome measures: age-specific and age-standardized (Italian 1981 census population as standard) incidence rates, by diagnostic group, sex and period of diagnosis. Time trend in incidence was analysed by using a Poisson regression model adjusted for calendar year, sex and 5 year age-group, and was expressed as annual percent change (ARC) in rates. Results: in the period 1972-2003, the new cases of cancer were 168 in the age-group 0-14years, 79 in the age-group 15-19yean and 111 in the age-group 20-24 years, while the person-years at risk were respectively: 1,050,027;431,673;496,450. The ARC in the incidence of all cancers combined was 2.3{\%} (IC 95{\%} 0.6{\%}-3.9{\%}) in children, 4.4{\%} (IC95{\%} 1.8{\%}-7.1{\%}) in adolescents and 5.1{\%} (IC 95{\%} 2.8{\%}-75{\%}) in young adults. Hodgkin lymphomas (ARC =12.7{\%}; IC95{\%} 2.6{\%}-23.7{\%}; 7 cases) in the age-group 0-14 years, skin melanomas and carcinomas (APC =8.2{\%}; IC95{\%} 4.5{\%} - 12.0{\%}; 49 cases) and central nervous system tumours (APC = 6.4{\%}; IC95{\%} 1.5{\%}-11.5{\%}; 25 cases) in the age-group 15-24 years were the malignancies characterised by the highest increase in incidence. Conclusion: the increase in incidence rates observed in this study can be only partly explained by the small number of ascertained cases, by an improvement in diagnostic techniques and by more efficient registration. However, few environmental and hereditary factors are consistently associated with cancers affecting young people. Therefore, it is imperative to continue to carry out descriptive and analytical studies with primary prevention as the ultimate aim.",
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AU - Brunetti, Davide

AU - Tamaro, Paolo

AU - Tiribelli, Mario

AU - Fanin, Renato

AU - Stanta, Giorgio

AU - Zanazzo, Giulio Andrea

AU - Peruzzo, Paolo

AU - Carobolante, Francesca

AU - Kiren, Valentina

AU - Serraino, Diego

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N2 - Objective: to report and analyse time trends in cancer incidence among children (0-14 years of age), adolescents (15-19 years) and young adults (20-24 years) living in the Italian province of Trieste (2003population, 242,000), between 1972and2003. Design: population-based study of descriptive epidemiology. Setting and participants: the new cases of cancer diagnosed to the residents of the province of Trieste below 25 years of age were extracted from the database of the Trieste Cancer Registry (period 1972-1994) and from the database of the Friuli-Venezia Giulia Cancer Registry (period 1995-2003), according to the International Classification of Childhood Cancer (3rd edition). Main outcome measures: age-specific and age-standardized (Italian 1981 census population as standard) incidence rates, by diagnostic group, sex and period of diagnosis. Time trend in incidence was analysed by using a Poisson regression model adjusted for calendar year, sex and 5 year age-group, and was expressed as annual percent change (ARC) in rates. Results: in the period 1972-2003, the new cases of cancer were 168 in the age-group 0-14years, 79 in the age-group 15-19yean and 111 in the age-group 20-24 years, while the person-years at risk were respectively: 1,050,027;431,673;496,450. The ARC in the incidence of all cancers combined was 2.3% (IC 95% 0.6%-3.9%) in children, 4.4% (IC95% 1.8%-7.1%) in adolescents and 5.1% (IC 95% 2.8%-75%) in young adults. Hodgkin lymphomas (ARC =12.7%; IC95% 2.6%-23.7%; 7 cases) in the age-group 0-14 years, skin melanomas and carcinomas (APC =8.2%; IC95% 4.5% - 12.0%; 49 cases) and central nervous system tumours (APC = 6.4%; IC95% 1.5%-11.5%; 25 cases) in the age-group 15-24 years were the malignancies characterised by the highest increase in incidence. Conclusion: the increase in incidence rates observed in this study can be only partly explained by the small number of ascertained cases, by an improvement in diagnostic techniques and by more efficient registration. However, few environmental and hereditary factors are consistently associated with cancers affecting young people. Therefore, it is imperative to continue to carry out descriptive and analytical studies with primary prevention as the ultimate aim.

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KW - Incidence

KW - Malignant tumours

KW - Time trend

KW - Young people

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